Featured Research

from universities, journals, and other organizations

Stem Cell Transplants May Be Effective For Multiple Sclerosis Patients

Date:
April 17, 2002
Source:
American Academy Of Neurology
Summary:
There’s a potential new treatment for people with severe cases of multiple sclerosis, according to research presented during the American Academy of Neurology’s 54th Annual Meeting in Denver, Colo., April 13-20, 2002. The new treatment involves removing stem cells from the patients’ blood, killing the cells that are working against the body’s immune system and then returning the healthy cells back to the body.

DENVER, CO – There’s a potential new treatment for people with severe cases of multiple sclerosis, according to research presented during the American Academy of Neurology’s 54th Annual Meeting in Denver, Colo., April 13-20, 2002. The new treatment involves removing stem cells from the patients’ blood, killing the cells that are working against the body’s immune system and then returning the healthy cells back to the body.

Related Articles


“The hope is that these stem cells will eventually reconstitute into healthy immune system cells and the disease process can be stopped,” said study author George Kraft, MD, MS, of the University of Washington Medical Center in Seattle.

For the study, 26 people with severe MS underwent this treatment, which is called autologous stem cell transplantation. Their results were followed for an average of 14.2 months. Conventional treatments had previously been unsuccessful for all of the patients, either because they had no improvement or were not able to tolerate the side effects.

Fifteen of the patients had tried multiple treatments with no success. After the stem cell transplant, 20 patients were stable, with no change in their amount of disability. Six patients showed some degree of mild improvement in some measures, Kraft said.

“This is good news,” said Kraft. “These patients had all been rapidly deteriorating over the past year, so to get them to a point where they are stabilized is great progress.”

In the 12 months prior to the study, all of the patients had deteriorated by one or more points on a scale that measures MS disability. For those patients who improved during the study, improvement was up to one-half point on the scale.

At one year after the transplant, only three patients had new brain lesions, which are a result of MS disease activity. Only two of the patients have needed to take MS disease-modifying drugs since the transplant, Kraft said.

Kraft said the treatment needs to be studied on more patients to confirm its effectiveness and studies are also needed to determine its long-term effect.

Some patients had complications following the procedure. One patient, who was the only patient to receive one form of an immunosuppressive drug used in the study due to a reaction to the other form of the drug, developed viruses that can affect transplant patients and died several weeks later. Another patient developed Guillain-Barre syndrome and pneumonia 17 months after the transplant. And one patient had a fever with no known cause soon after the transplant and, as a result, worsened by one point on the disability scale.

The American Academy of Neurology, an association of more than 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research.

For more information about the American Academy of Neurology, visit its web site at http://www.aan.com.


Story Source:

The above story is based on materials provided by American Academy Of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy Of Neurology. "Stem Cell Transplants May Be Effective For Multiple Sclerosis Patients." ScienceDaily. ScienceDaily, 17 April 2002. <www.sciencedaily.com/releases/2002/04/020417070731.htm>.
American Academy Of Neurology. (2002, April 17). Stem Cell Transplants May Be Effective For Multiple Sclerosis Patients. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2002/04/020417070731.htm
American Academy Of Neurology. "Stem Cell Transplants May Be Effective For Multiple Sclerosis Patients." ScienceDaily. www.sciencedaily.com/releases/2002/04/020417070731.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins