Featured Research

from universities, journals, and other organizations

Implant May Stabilize Schizophrenia Patients' Treatment

Date:
May 29, 2002
Source:
University Of Pennsylvania Medical Center
Summary:
One of the greatest difficulties in treating schizophrenia has always been helping patients to stay on their medication. Now, that problem is closer to being solved. Scientists at the University of Pennsylvania's School of Medicine have designed an implantable device capable of delivering anti-psychotic medication for a period of five months, and continuing work at Penn indicates that such devices may work for up to a full year.

(Philadelphia, PA) -- One of the greatest difficulties in treating schizophrenia has always been helping patients to stay on their medication. Now, that problem is closer to being solved.

Scientists at the University of Pennsylvania's School of Medicine have designed an implantable device capable of delivering anti-psychotic medication for a period of five months, and continuing work at Penn indicates that such devices may work for up to a full year. The device has been proven effective in initial laboratory studies, and more research is underway (in collaboration with the University of Pittsburgh School of Medicine) to lead to potential clinical trials.

Findings from the small-mammal study appear in the current issue of the scientific journal Neuropsychopharmacology. If the device can be demonstrated to work effectively in human subjects in future trials, it will offer a medical alternative that may relieve many patients of the threat of psychosis and chronic social instability.

"Schizophrenia destroys an individual's grasp of reality, robbing him of his identity and devastating his family," said Steven Siegel, MD, PhD, of the Division of Neuropsychiatry in Penn's Department of Psychiatry. This device could relieve those threats, by assuring medical stability.

"Patients who need anti-psychotic drugs often fail to comprehend the profound severity of their illness, and may stop taking their medication during temporary periods of impaired judgement. But when the majority of patients with psychiatric disorders take appropriate medicine, they do achieve periods of remission from psychotic symptoms." Siegel said. "The advantage of relying on an implantable anti-psychotic medicine is that patients are able to make decisions about the future course of their treatment during periods of relative health, but if a medical reason arises that necessitates curtailing treatment, the implant can be easily removed."

The delivery device consists of a surgically-implantable disc made of biodegradable polymers (a series of linked molecules) combined with medication. In the trials, a traditional anti-psychotic medicine, Haloperidol, was used. The discs have been modeled in a fashion that allows each type of polymer to disintegrate at a specific rate, so that exactly the prescribed volume of medication is released into the bloodstream each day for up to a year. About the size of a quarter, the device is held in place under the skin with a single surgical stitch. According to Siegel, the implantation procedure (and removal procedure) can be performed in about 15 minutes under local anesthetic.

Other Penn researchers who collaborated in the study are: Karen I. Winey, PhD, Department of Materials Science and Engineering; Raquel Gur, MD, PhD, and Robert H. Lenox, MD, Department of Psychiatry; Warren B. Bilker, PhD, Department of Biostatistics and Epidemiology, and Debbie Ikeda, Neel Gandhi, and Wen-Xiao Zhang, MS, also of Psychiatry.

Siegel's work is supported by the Stanley Foundation, an advocacy organization for families of individuals afflicted with schizophrenia. He has been named director of the newly formed Stanley Center for Experimental Therapeutics in Psychiatry at Penn. A patent application for the implant technology is pending.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "Implant May Stabilize Schizophrenia Patients' Treatment." ScienceDaily. ScienceDaily, 29 May 2002. <www.sciencedaily.com/releases/2002/05/020529071759.htm>.
University Of Pennsylvania Medical Center. (2002, May 29). Implant May Stabilize Schizophrenia Patients' Treatment. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2002/05/020529071759.htm
University Of Pennsylvania Medical Center. "Implant May Stabilize Schizophrenia Patients' Treatment." ScienceDaily. www.sciencedaily.com/releases/2002/05/020529071759.htm (accessed October 20, 2014).

Share This



More Mind & Brain News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Court Ruling Means Kids' Online Activity Could Be On Parents

Court Ruling Means Kids' Online Activity Could Be On Parents

Newsy (Oct. 17, 2014) In a ruling attorneys for both sides agreed was a first of its kind, a Georgia appeals court said parents can be held liable for what kids put online. Video provided by Newsy
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
You Can Get Addicted To Google Glass, Apparently

You Can Get Addicted To Google Glass, Apparently

Newsy (Oct. 15, 2014) Researchers claim they’ve diagnosed the first example of the disorder in a 31-year-old U.S. Navy serviceman. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins