Featured Research

from universities, journals, and other organizations

Even Mild Vitamin C Deficiency May Have Negative Effect On Vascular Function

Date:
June 7, 2002
Source:
University Of Pittsburgh Medical Center
Summary:
Research being presented at the 13th World Congress of the International Society for the Study of Hypertension in Pregnancy by scientists from the Magee-Womens Research Institute and the University of Pittsburgh School of Medicine suggests even a mild deficiency in vitamin C appears to negatively affect vascular elasticity and function – a key symptom of preeclampsia.

TORONTO, June 4 – Every six minutes, a woman dies of a pregnancy complication called preeclampsia – nine women an hour, according to the Preeclampsia Foundation. The disorder, which is linked to hypertension and affects 3 million women a year worldwide, can be equally devastating for infants.

Now, research being presented at the 13th World Congress of the International Society for the Study of Hypertension in Pregnancy by scientists from the Magee-Womens Research Institute and the University of Pittsburgh School of Medicine suggests even a mild deficiency in vitamin C appears to negatively affect vascular elasticity and function – a key symptom of preeclampsia.

“Research is closing in on this menace,” said James M. Roberts, M.D., professor and chairman of research in the department of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine, director of the Magee-Womens Research Institute and president of the International Society for the Study of Hypertension in Pregnancy. “But there is still much to do.”

Carl A. Hubel, Ph.D., assistant professor of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine, and his colleagues studied arterial pressure and elasticity in pregnant and non-pregnant rats that, like humans, are unable to synthesize vitamin C.

Dr. Hubel’s group found that blood vessel stiffness increased in pregnant rats when vitamin C concentrations were restricted. Non-pregnant animals were not similarly affected by vitamin C restriction, however.

These results were observed despite a natural physiologic change initiated by pregnancy that typically increases blood vessel elasticity, which in turn affects blood pressure. While researchers have long known that vitamin C concentrations are decreased in women with preeclampsia, the specific effect on vascular function remains unclear, according to Dr. Hubel, who is also an investigator with the Magee-Womens Research Institute.

Women who have previously experienced preeclampsia, also known as toxemia and characterized by high blood pressure, swollen ankles and the presence of protein in the urine, have an even greater chance of developing the disorder in subsequent pregnancies. Other risk factors include maternal age of less than 25 or more than 35 years and preexisting hypertension, diabetes or kidney disease.

“Preeclampsia is one of the leading causes of maternal, fetal and neonatal disability and death,” said Dr. Roberts.

Magee-Womens Research Institute, the country’s first institute devoted to women and infants, was formed in 1992 by Magee-Womens Hospital of the UPMC Health System. The University of Pittsburgh School of Medicine’s department of obstetrics, gynecology and reproductive sciences is one of the top three funded departments by the National Institutes of Health.

Members of the International Society for the Study of Hypertension in Pregnancy meet formally every two years to exchange ideas and foster collaboration. Membership includes physicians and researchers in the fields of obstetrics, gynecology, epidemiology and other public health specialties.


Story Source:

The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pittsburgh Medical Center. "Even Mild Vitamin C Deficiency May Have Negative Effect On Vascular Function." ScienceDaily. ScienceDaily, 7 June 2002. <www.sciencedaily.com/releases/2002/06/020605073010.htm>.
University Of Pittsburgh Medical Center. (2002, June 7). Even Mild Vitamin C Deficiency May Have Negative Effect On Vascular Function. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2002/06/020605073010.htm
University Of Pittsburgh Medical Center. "Even Mild Vitamin C Deficiency May Have Negative Effect On Vascular Function." ScienceDaily. www.sciencedaily.com/releases/2002/06/020605073010.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins