Featured Research

from universities, journals, and other organizations

Novel Diagnostic Tool Detects Life-Threatening Infections Faster Than Standard Nuclear Imaging Tests

Date:
June 19, 2002
Source:
Cedars-Sinai Medical Center
Summary:
Researchers at Cedars-Sinai Medical Center have found that a novel imaging agent detects life-threatening infections and inflammation in patients more rapidly than the standard nuclear medicine imaging tests typically used for this purpose. The imaging agent may eliminate the need for additional tests and reduce the risk of exposure involved in handling blood samples taken when additional clarification is needed to identify the infection.

LOS ANGELES, CA -- Researchers at Cedars-Sinai Medical Center have found that a novel imaging agent detects life-threatening infections and inflammation in patients more rapidly than the standard nuclear medicine imaging tests typically used for this purpose. The imaging agent may eliminate the need for additional tests and reduce the risk of exposure involved in handling blood samples taken when additional clarification is needed to identify the infection.

The study, presented at the 49th Annual Meeting of the Society of Nuclear Medicine, sought to determine whether the agent, a non-invasive radiopharmaceutical recently FDA approved for the detection of lung cancer, was effective in identifying the presence of infection or inflammation. The investigators found that the imaging agent, called Tc 99m Depreotide detected the source of the infection in all patients studied three hours after they received the agent. Infection and inflammations included pneumonia, infections of bone, kidney, lining of the heart, gallbladder, skin and joint prosthesis.

"Our results show that a Depreotide scan identified the source of infection in all patients who had successfully undergone other types of nuclear imaging tests to determine the cause of infection," said Alan Waxman, M.D., the lead author of the study and the Director of Nuclear Medicine and Co-Chairman of Imaging at Cedars-Sinai Medical Center. "In short, Depreotide enabled us to determine the presence of infection about three hours after the patient underwent a Depreotide scan when it usually takes as long as 24 to 48 hours to get results. This means that medical decisions can be made much more rapidly and accurately when a patient's life may be at stake."

Typically, radiologists use nuclear imaging tests such as labeled white blood cells or other radio tracers to help identify the type and source of infection when patients present with fever or other signs of infection. These tests detect infection by slowly concentrating in areas where white blood cells have collected to fight infection. The detection of abnormality often depends on the concentration of the tracer over many hours or days before the abnormalities are visualized. Test results can take from 24 to 48 hours and require laboratory technicians to handle blood products, which can expose them to HIV or AIDS.

The imaging agent, Depreotide, is a small synthetic peptide that works by attaching to proteins called somatostatin receptors, which are present on lung cancer cell surfaces. And, because a large number of these receptors are present on lung cancer cells, the agent concentrates on the cells and provides clear images of the tumor. But some infection and inflammatory processes also involve the expression of somatostatin receptors on cell surfaces, leading Dr. Waxman and his research team to examine whether the agent could provide clear images of the infection.

To determine whether Depreotide could detect infection more rapidly and accurately than traditional imaging tests, 19 patients with 21 previously identified sources of infection/inflammation were given an injection of Tc-99m Depreotide and underwent whole body imaging scans with a nuclear medicine camera two hours later. Infection/inflammation was detected in all patients studied, sometimes more accurately than other tests, including CT scans.

The investigators found that Depreotide was able to detect the source of infection in all or 100 percent of the patients with previously identified infections within a three-hour time period.

"Our results suggest that this agent is capable of detecting infections within three hours after receiving an injection of Depreotide without handling blood products or having to perform extra imaging studies," said Dr. Waxman.

This study was supported by a grant from Berlex Laboratories, Inc. Further studies will investigate the type of infection that is best characterized by the Depreotide agent.

Cedars-Sinai Medical Center is one of the largest nonprofit academic medical centers in the Western United States. For the fifth straight two-year period, Cedars-Sinai has been named Southern California's gold standard in health care in an independent survey. Cedars-Sinai is internationally renowned for its diagnostic and treatment capabilities and its broad spectrum of programs and services, as well as breakthrough in biomedical research and superlative medical education. Named one of the 100 "Most Wired" hospitals in health care in 2001, the Medical Center ranks among the top 10 non-university hospitals in the nation for its research activities.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Novel Diagnostic Tool Detects Life-Threatening Infections Faster Than Standard Nuclear Imaging Tests." ScienceDaily. ScienceDaily, 19 June 2002. <www.sciencedaily.com/releases/2002/06/020619074639.htm>.
Cedars-Sinai Medical Center. (2002, June 19). Novel Diagnostic Tool Detects Life-Threatening Infections Faster Than Standard Nuclear Imaging Tests. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2002/06/020619074639.htm
Cedars-Sinai Medical Center. "Novel Diagnostic Tool Detects Life-Threatening Infections Faster Than Standard Nuclear Imaging Tests." ScienceDaily. www.sciencedaily.com/releases/2002/06/020619074639.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins