Featured Research

from universities, journals, and other organizations

Aspirin's Target, The COX-2 Enzyme, Linked To Cancer Of The Uterus

Date:
July 18, 2002
Source:
University Of Illinois At Chicago
Summary:
A researcher at the University of Illinois at Chicago College of Medicine has discovered a link between cancer of the uterus and the COX-2 enzyme, a compound first implicated in the painful inflammation associated with arthritis and more recently in the spread of colon cancer.

A researcher at the University of Illinois at Chicago College of Medicine has discovered a link between cancer of the uterus and the COX-2 enzyme, a compound first implicated in the painful inflammation associated with arthritis and more recently in the spread of colon cancer.

Related Articles


Nationally, cancer of the uterus is the most common cancer of the female reproductive system, accounting for 6 percent of all cancers in U.S. women.

In a laboratory study, Dr. Serdar Bulun, director of reproductive endocrinology and infertility and a member of the UIC Cancer Center, cultured malignant epithelial cells from the lining of the uterus alongside normal cells from the same kind of tissue.

In the interaction between normal and malignant cells, the malignant tissue induced the normal tissue to increase production of the enzyme cyclooxydase-2 (COX-2). Levels of certain prostaglandins also rose, hormone-like substances synthesized by COX-2.

As Bulun and other researchers have shown, COX-2 and its product prostaglandins set off a cascade of molecular events, including an abnormal increase in estrogen, that leads to tumor growth.

"The findings suggest that everyday drugs like aspirin or ibuprofen -- nonsteroidal anti-inflammatory drugs that block the COX-2 enzyme -- might be tried as treatments for uterine cancer in combination with other therapies," Bulun said.

Results of the study will be published in the July 17 issue of the Journal of Biological Chemistry.

The prostaglandins synthesized by COX-2 are mediators of inflammation, the body's response to injury characterized by increased blood flow to the tissue, increased temperature, redness, accumulation of immune cells and pain.

Bulun has found increased levels of COX-2 and its product prostaglandins in endometriosis, a painful, inflammatory disease in which endometrial tissue from the lining of the uterus attaches to other organs, including the ovaries, fallopian tubes, and sometimes the gut and rectum, causing internal bleeding, chronic pelvic pain and even infertility.

COX-2 and prostaglandins are also involved in the spread of tumors, such as in colon cancer. They reduce the rate of cell death, increase the invasiveness of the malignancies and promote the growth of blood vessels that deliver nourishment to the lesions. Currently, drugs that inhibit COX-2 are prescribed in the treatment of precancerous polyps in the colon and colon cancer, where cells have increased levels of the enzyme.

In previous research, Bulun found that the prostaglandins manufactured by COX-2 stimulate the production of estrogen. Cancer of the uterus, as well as certain kinds of breast cancer and endometriosis, depends on estrogen for fuel, and estrogen itself drives the manufacture of prostaglandins.

"You see how crafty this cancer is," Bulun said. "By encouraging the production of COX-2, it sets in motion a continuous cycle whereby the tumor can thrive and grow."

In two additional articles published in the July issue of the Journal of Clinical Endocrinology and Metabolism, Bulun demonstrates that two other molecules also increase production of COX-2. One molecule, called vascular endothelial growth factor, is involved in promoting the growth of blood vessels that feed the growing pathological tissue. The other molecule, interleukin-1beta, is a small molecule associated with the immune system, which deploys cells to sites where foreign tissue has invaded.

"These findings suggest that cancer of the uterus finds multiple ways of ensuring its survival," Bulun said.

For more information about the UIC Cancer Center, see http://www.uic.edu/com/cancer.

For more information about UIC, see http://www.uic.edu


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "Aspirin's Target, The COX-2 Enzyme, Linked To Cancer Of The Uterus." ScienceDaily. ScienceDaily, 18 July 2002. <www.sciencedaily.com/releases/2002/07/020718075705.htm>.
University Of Illinois At Chicago. (2002, July 18). Aspirin's Target, The COX-2 Enzyme, Linked To Cancer Of The Uterus. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2002/07/020718075705.htm
University Of Illinois At Chicago. "Aspirin's Target, The COX-2 Enzyme, Linked To Cancer Of The Uterus." ScienceDaily. www.sciencedaily.com/releases/2002/07/020718075705.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins