Featured Research

from universities, journals, and other organizations

Researchers Identify Gene Involved In Autoimmune Disease

Date:
July 26, 2002
Source:
University Of Virginia Health System
Summary:
Researchers have identified a gene that appears to be a critical factor in autoimmune disease, according to a study to be published in the July 26 issue of Science. The research, performed by scientists at the University of Virginia and the University of Vermont Schools of Medicine and colleagues at other universities, might provide a unique view at the molecular defects underlying autoimmune disease.

CHARLOTTESVILLE, Va., July 25 – Researchers have identified a gene that appears to be a critical factor in autoimmune disease, according to a study to be published in the July 26 issue of Science. The research, performed by scientists at the University of Virginia and the University of Vermont Schools of Medicine and colleagues at other universities, might provide a unique view at the molecular defects underlying autoimmune disease.

Using molecular techniques to study the genetic material from autoimmune disease-susceptible mice, scientists were able to identify a region of the mouse chromosome, and subsequently a gene, that correlates with autoimmune disease. The gene of interest encodes a protein that functions as a receptor for histamine, a signaling molecule involved in immune responses.

Autoimmune disease, a disorder that occurs when an affected individual's immune system launches attacks on its own tissue confusing itself as a foreign invader, is responsible for various disorders such as multiple sclerosis and rheumatoid arthritis.

Present therapies for autoimmune disease, which merely suppress the affected individual's immune system, necessitate new and more specific treatments, said Dr. Kenneth S. K. Tung, professor of pathology at the University of Virginia and co-investigator of the study.

"Utilizing a mouse model to study autoimmune disease will have a definite impact on the understanding of human autoimmune disease as genes that cause disease in mice have been found to be concordant with autoimmune causing genes in humans," Tung said. "The next progression of this study will be to understand the role of the histamine receptor in autoimmune disease and, more importantly, to determine whether a parallel set of events occurs in human autoimmune disease."

The research presented in this study hopefully will prove significant not only for the understanding of autoimmune disease but also for other illnesses. "It's becoming clear that the responses and regulatory elements that cause autoimmune disease also apply to the body's response to cancer and tissue grafts. So if we can understand how autoimmune disease is regulated, then you can apply the same knowledge to prevent tissue graft rejection or promote cancer immunity and improve vaccine effects," Tung said.


Story Source:

The above story is based on materials provided by University Of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University Of Virginia Health System. "Researchers Identify Gene Involved In Autoimmune Disease." ScienceDaily. ScienceDaily, 26 July 2002. <www.sciencedaily.com/releases/2002/07/020726081146.htm>.
University Of Virginia Health System. (2002, July 26). Researchers Identify Gene Involved In Autoimmune Disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2002/07/020726081146.htm
University Of Virginia Health System. "Researchers Identify Gene Involved In Autoimmune Disease." ScienceDaily. www.sciencedaily.com/releases/2002/07/020726081146.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins