Featured Research

from universities, journals, and other organizations

Bile Acid Inhibits Cell Death In Huntington's Disease

Date:
July 30, 2002
Source:
University Of Minnesota
Summary:
University of Minnesota researchers have found that a nontoxic bile acid produced in the body prevents apoptosis, or programmed cell death, in mice with Huntington's disease. This finding, to be published July 29 in the Proceedings of the National Academy of Sciences USA (PNAS), may eventually lead to a treatment for Huntington's disease (HD) in humans.

MINNEAPOLIS / ST. PAUL (July 24, 2002)--University of Minnesota researchers have found that a nontoxic bile acid produced in the body prevents apoptosis, or programmed cell death, in mice with Huntington's disease. This finding, to be published July 29 in the Proceedings of the National Academy of Sciences USA (PNAS), may eventually lead to a treatment for Huntington's disease (HD) in humans. HD is an untreatable neurological disorder caused by selective and progressive degeneration of neural cells.

In the study, led by Walter Low, Ph.D., professor of neurosurgery in the university's Medical School, a dose of tauroursodeoxycholic acid (TUDCA) was administered subcutaneously once every third day for six weeks in mice with the HD gene. Researchers found TUDCA was able to cross the blood / brain barrier, something many molecules are unable to do, resulting in decreased apoptosis in the section of the brain affected by HD and improving the neurological cell function in the mice.

"We're extremely encouraged by the neuroprotective function of TUDCA in Huntington's disease and will be examining its potential in future studies," said Low.

The bile acid's anti-apoptotic qualities were originally discovered in the laboratory of Clifford Steer, M.D., co-author of the article and director of the university's molecular gastroenterology program.

"We determined that this bile acid was unique in its ability to maintain the integrity of mitochondria, which is so important for normal cell function," said Steer. "By so doing, the TUDCA was able to significantly reduce brain cell death in a variety of conditions, including acute stroke, in rats. We were interested to see if this would be the case in Huntington's disease as well. What's exciting about TUDCA, in addition to its remarkable anti-apoptotic quality, is that it's made in our own bodies and causes virtually no side effects when given as a drug. TUDCA may even have potential for treating other chronic neurodegenerative conditions, such as Parkinson's, Alzheimer's and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)."

Orally administered ursodeoxycholic acid, the parent molecule, is already FDA-approved for the treatment of primary biliary cirrhosis.

Other authors of the study include C. Dirk Keene, Cecilia M.P. Rodrigues, Tacjana Eich, and Manik S. Chhabra.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Bile Acid Inhibits Cell Death In Huntington's Disease." ScienceDaily. ScienceDaily, 30 July 2002. <www.sciencedaily.com/releases/2002/07/020730075921.htm>.
University Of Minnesota. (2002, July 30). Bile Acid Inhibits Cell Death In Huntington's Disease. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2002/07/020730075921.htm
University Of Minnesota. "Bile Acid Inhibits Cell Death In Huntington's Disease." ScienceDaily. www.sciencedaily.com/releases/2002/07/020730075921.htm (accessed October 22, 2014).

Share This



More Mind & Brain News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
Portable Breathalyzer Gets You Home Safely

Portable Breathalyzer Gets You Home Safely

Buzz60 (Oct. 21, 2014) Breeze, a portable breathalyzer, gets you home safely by instantly showing your blood alcohol content, and with one tap, lets you call an Uber, a cab or a friend from your contact list to pick you up. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Movies Might Desensitize Violence For Parents, Not Just Kids

Movies Might Desensitize Violence For Parents, Not Just Kids

Newsy (Oct. 20, 2014) A study suggests that parents become desensitized to violent movies as well as children, which leads them to allow their kids to view violent films. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins