Featured Research

from universities, journals, and other organizations

Breast Cancer Gene May Be Associated With Additional Cancers

Date:
September 18, 2002
Source:
Journal Of The National Cancer Institute
Summary:
Two new studies suggest that people who inherit BRCA1 mutations are at an increased risk of not only breast and ovarian cancer but a number of other cancers as well. However, the absolute magnitude of the increase in risk of these other cancers is small. The findings appear in the September 18 issue of the Journal of the National Cancer Institute.

Two new studies suggest that people who inherit BRCA1 mutations are at an increased risk of not only breast and ovarian cancer but a number of other cancers as well. However, the absolute magnitude of the increase in risk of these other cancers is small. The findings appear in the September 18 issue of the Journal of the National Cancer Institute.

Mutations in the BRCA1 tumor suppressor gene have been associated with a marked increase in the risk of breast and ovarian cancer. Several studies have examined the association of BRCA1 with other cancers, particularly prostate cancer and colon cancer, but the results have been mixed.

To clarify this connection, Deborah Thompson, Ph.D., and Douglas F. Easton, Ph.D., of the University of Cambridge, and their colleagues from the Breast Cancer Linkage Consortium estimated cancer risk rates among 11,847 people from families with a history of breast and/or ovarian cancer and in which at least one family member was a BRCA1 mutation carrier.

They found small but statistically significant increases in the risk of colon, liver, pancreatic, uterine, and cervical cancers among female BRCA1 mutation carriers, compared with the general population. In male BRCA1 mutation carriers, there was a slightly elevated risk of prostate cancer. However, this increase was seen only in men younger than age 65.

In the second study, Marcia S. Brose, M.D., Ph.D., and Barbara L. Weber, M.D., of the University of Pennsylvania Cancer Center, and their colleagues used a different method to estimate BRCA1-related cancer risks among 483 mutation carriers identified through a cancer risk counseling program. Some of the participants were the same ones used in the first study.

Over their lifetimes, BRCA1 mutation carriers had an estimated 73% risk of breast cancer and 41% risk of ovarian cancer, compared with risks of 13% and 2%, respectively, in the general population. In addition, mutation carriers had a small increase in risk of colon, pancreatic, and gastric cancers. Although the risk of fallopian tube cancer increased 120-fold, the authors point out that this cancer is extremely rare in the general population.

Stephen B. Gruber, M.D., Ph.D., of the University of Michigan, Ann Arbor, and Gloria M. Petersen, Ph.D., of the Mayo Clinic in Rochester, Minn., emphasize the importance of accuracy in estimating cancer risk among mutation carriers because these estimates influence choices regarding screening, chemoprevention, and prophylactic surgery.

"Both of these studies provide intriguing new patterns to investigate further, and it is now time for the next generation of studies to follow each lead more directly," they write in an accompanying editorial. "In the meantime, the message is that the major cancer risks conferred by BRCA1 are related to cancers of the breast, ovary, and fallopian tube, but increased risks of other cancers are likely to be small."


Story Source:

The above story is based on materials provided by Journal Of The National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The National Cancer Institute. "Breast Cancer Gene May Be Associated With Additional Cancers." ScienceDaily. ScienceDaily, 18 September 2002. <www.sciencedaily.com/releases/2002/09/020918064514.htm>.
Journal Of The National Cancer Institute. (2002, September 18). Breast Cancer Gene May Be Associated With Additional Cancers. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2002/09/020918064514.htm
Journal Of The National Cancer Institute. "Breast Cancer Gene May Be Associated With Additional Cancers." ScienceDaily. www.sciencedaily.com/releases/2002/09/020918064514.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins