Featured Research

from universities, journals, and other organizations

Growing Evidence That Commonly Used Medicines May Delay Or Prevent Alzheimer’s Disease

Date:
September 24, 2002
Source:
American Academy Of Neurology
Summary:
Have researchers found yet another reason to take an aspirin a day? Aspirin has been found to benefit cardiac patients. Now a new study reported in the current issue of Neurology, the scientific journal of the American Academy of Neurology, presents additional evidence that regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the incidence of dementia in elderly people, but only when taken for more than two years.

ST. PAUL, MN – Have researchers found yet another reason to take an aspirin a day? Aspirin has been found to benefit cardiac patients. Now a new study reported in the current issue of Neurology, the scientific journal of the American Academy of Neurology, presents additional evidence that regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the incidence of dementia in elderly people, but only when taken for more than two years. Researchers assessed 5,092 elderly (aged 65+) residents of Cache County, Utah, for dementia, while noting their current and former use of NSAIDs, aspirin compounds or histamine H2 receptor antagonists (including cimetidine, ranitidine, famitidine and nizatidine). Three years later they obtained interval medication histories and identified 104 participants with Alzheimer's disease among the 3,227 living participants.

Related Articles


"Our results suggest that long-term NSAID use may reduce the risk of AD, provided the use occurs well before the onset of dementia," said John Breitner, MD, VA Puget Sound Health Care System, Seattle, WA, and one of 22 investigators who conducted the study. Breitner added that recent use of NSAIDs and aspirin appears to offer little protection.

Those who started taking NSAIDs near the start of the study or later appeared to receive little protection from Alzheimer's disease. But earlier long term use (more than two years) was associated with an incidence rate that was only 45 percent of the rate seen in non-users. There was a trend toward even greater risk reduction among those with the longest history of taking the medications. Results were similar for regular use of aspirin, but not for any other medicines examined.

Medicines included in the study were aspirin compounds, non-aspirin NSAIDs (including ibuprofen, naproxen, diclofenac, nabumetone, sulindac, and oxaprozin), and histamine H2 receptor antagonists. Other medicines were included as controls and, as expected, did not have any effect on the risk of Alzheimer's disease. These were pain relievers such as acetaminophen, allopurinol, propoxyphene and other opoids; antacids and antiflatulants; and other stomach remedies.

Current trials of NSAIDs for primary prevention of Alzheimer's disease probably won't show effects with treatment until participants have been followed for several years, according to Breitner.

The study was supported by a grant from the National Institute on Aging, part of the National Institutes of Health. The American Academy of Neurology, an association of more than 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. For more information about the American Academy of Neurology, visit its website at http://www.aan.com.


Story Source:

The above story is based on materials provided by American Academy Of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy Of Neurology. "Growing Evidence That Commonly Used Medicines May Delay Or Prevent Alzheimer’s Disease." ScienceDaily. ScienceDaily, 24 September 2002. <www.sciencedaily.com/releases/2002/09/020924072355.htm>.
American Academy Of Neurology. (2002, September 24). Growing Evidence That Commonly Used Medicines May Delay Or Prevent Alzheimer’s Disease. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2002/09/020924072355.htm
American Academy Of Neurology. "Growing Evidence That Commonly Used Medicines May Delay Or Prevent Alzheimer’s Disease." ScienceDaily. www.sciencedaily.com/releases/2002/09/020924072355.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins