Featured Research

from universities, journals, and other organizations

Virginia Commonwealth University Scientists Growing Synthetic Blood Vessels

Date:
November 27, 2002
Source:
Virginia Commonwealth University
Summary:
Traditional heart bypass surgeries require using veins from the leg to replace damaged blood vessels. Using a nanotechnology developed by Virginia Commonwealth University researchers, doctors soon could be using artificial blood vessels grown in a laboratory to help save half a million lives every year.

RICHMOND, Va. – Traditional heart bypass surgeries require using veins from the leg to replace damaged blood vessels. Using a nanotechnology developed by Virginia Commonwealth University researchers, doctors soon could be using artificial blood vessels grown in a laboratory to help save half a million lives every year.

The new technology produces a natural human blood vessel grown around a scaffold, or tube, made of collagen. Using a process called electrospinning, VCU scientists are making tubes as small as one millimeter in diameter. That’s more than four times smaller than the width of a drinking straw and six times smaller than the smallest commercially available vascular graft.

VCU Biomedical Engineer Gary L. Bowlin, Ph.D., said patients don’t always have enough spare veins for a heart bypass, and even when they do, complications and failures often result because they are not compatible. “So what’s really needed is a blood vessel you can pull off the shelf,” said Bowlin.

After the scaffold is spun, smooth muscle cells are “seeded” or placed on its surface in a laboratory. The cells grow and within three-to-six weeks the tissue-engineered blood vessel is ready to implant.

Unlike current synthetic plastic blood vessels, collagen is a natural component of the body, allowing cells to grow on its surface and avoid rejection. “The cells are in a happy environment and they’re just going to stay and think ‘I’m a blood vessel, I’m going to act like a blood vessel,’” said Bowlin.

The collagen scaffold is biodegradable and eventually is replaced by the body. Pre-made blood vessels could be made available to emergency rooms where every second counts. Other applications include pediatric surgery where implanted blood vessels must grow with the patient and diabetic patients who often lose blood vessels to vascular disease.

The same collagen electrospinning technology can also be used to regenerate or replace skin, bone, nerves, muscles and even repair spinal cord injuries, according to co-inventor Gary E. Wnek, Ph.D., a VCU chemical engineer. “Anything you want to repair can start from a scaffold. We’re very excited about the potential,” said Wnek.

Practical applications of the new technology could be commercially available within three years.

About VCU: Virginia Commonwealth University is ranked by the Carnegie Foundation as one of the nation’s top research universities. Located on two campuses in Richmond, Va., VCU enrolls 26,000 students in more than 160 undergraduate, graduate, professional, doctoral and post-graduate certificate degree programs at 11 schools and one college. Sixteen graduate and professional programs have been ranked by U.S. News & World Report as among the best of their kind in the nation. The VCU Health System is one of the leading academic medical centers in the country. VCU recently launched VCU Life Sciences, a comprehensive undergraduate and graduate program involving academic and medical faculty. In addition, the university is developing the Virginia Biotechnology Research Park in collaboration with business, civic and government leaders. For more, see http://www.vcu.edu.


Story Source:

The above story is based on materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


Cite This Page:

Virginia Commonwealth University. "Virginia Commonwealth University Scientists Growing Synthetic Blood Vessels." ScienceDaily. ScienceDaily, 27 November 2002. <www.sciencedaily.com/releases/2002/11/021126210341.htm>.
Virginia Commonwealth University. (2002, November 27). Virginia Commonwealth University Scientists Growing Synthetic Blood Vessels. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2002/11/021126210341.htm
Virginia Commonwealth University. "Virginia Commonwealth University Scientists Growing Synthetic Blood Vessels." ScienceDaily. www.sciencedaily.com/releases/2002/11/021126210341.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins