Featured Research

from universities, journals, and other organizations

Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When

Date:
February 10, 2003
Source:
Rensselaer Polytechnic Institute
Summary:
The mind works in mysterious ways, and one Rensselaer researcher and his colleagues have created a computer automation tool to help solve those mysteries, speed understanding of how the brain develops, delve more deeply into brain function at the cellular level, and make more reliable conclusions.

TROY, N.Y. -- The mind works in mysterious ways, and one Rensselaer researcher and his colleagues have created a computer automation tool to help solve those mysteries, speed understanding of how the brain develops, delve more deeply into brain function at the cellular level, and make more reliable conclusions.

Rensselaer engineering professor Badri Roysam has developed a technology called Quantitative cat-FISH that analyzes 3-D, microscopic images of the brains of rats after the animals have run through mazes. By logging important cognitive cellular information -- such as activity, cell shape, size, and location -- in a simple spreadsheet for analysis, the software is helping researchers identify which cells are active and when. In the past, researchers have only been able to pinpoint which general regions of the brain are active.

Researchers used to perform some of the time-consuming cell counting and transcription work that Quantitative cat-FISH does by hand. Roysam's system now allows scientists to process more data and tissue faster and without subjective error. It also enables researchers to make more reliable conclusions.

"Quantitative cat-FISH" stands for Quantitative Cellular Compartment Analysis of Temporal Activity -- Fluorescence In-Situ Hybridization. It was developed by Roysam along with Jim Turner, director of the Wadsworth's Nanobiotechnology Program, and a team of scientists led by Carol Barnes, research scientist and professor of psychology and neurology at the University of Arizona.

"This is a powerful tool for large-scale and quantitative testing of biological hypotheses, especially when combined with related technologies developed at Rensselaer," says Roysam. "It can be used in many other areas of cell and molecular research."

The technology is currently being used to test hypotheses on the behavior of neurons grown over engineered surfaces, the development of tumor blood vessels, and the effects of polychlorinated biphenyls (PCBs) on river life forms.

Barnes says the software has proven to be a helpful tool in her team's studies of whether cognitive tasks trigger specific gene reactions. "We have made great progress over the last couple of years, and we couldn't have done it without RPI's image analysis technology," says Barnes.


Story Source:

The above story is based on materials provided by Rensselaer Polytechnic Institute. Note: Materials may be edited for content and length.


Cite This Page:

Rensselaer Polytechnic Institute. "Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When." ScienceDaily. ScienceDaily, 10 February 2003. <www.sciencedaily.com/releases/2003/02/030210075428.htm>.
Rensselaer Polytechnic Institute. (2003, February 10). Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2003/02/030210075428.htm
Rensselaer Polytechnic Institute. "Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When." ScienceDaily. www.sciencedaily.com/releases/2003/02/030210075428.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins