Featured Research

from universities, journals, and other organizations

Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When

Date:
February 10, 2003
Source:
Rensselaer Polytechnic Institute
Summary:
The mind works in mysterious ways, and one Rensselaer researcher and his colleagues have created a computer automation tool to help solve those mysteries, speed understanding of how the brain develops, delve more deeply into brain function at the cellular level, and make more reliable conclusions.

TROY, N.Y. -- The mind works in mysterious ways, and one Rensselaer researcher and his colleagues have created a computer automation tool to help solve those mysteries, speed understanding of how the brain develops, delve more deeply into brain function at the cellular level, and make more reliable conclusions.

Rensselaer engineering professor Badri Roysam has developed a technology called Quantitative cat-FISH that analyzes 3-D, microscopic images of the brains of rats after the animals have run through mazes. By logging important cognitive cellular information -- such as activity, cell shape, size, and location -- in a simple spreadsheet for analysis, the software is helping researchers identify which cells are active and when. In the past, researchers have only been able to pinpoint which general regions of the brain are active.

Researchers used to perform some of the time-consuming cell counting and transcription work that Quantitative cat-FISH does by hand. Roysam's system now allows scientists to process more data and tissue faster and without subjective error. It also enables researchers to make more reliable conclusions.

"Quantitative cat-FISH" stands for Quantitative Cellular Compartment Analysis of Temporal Activity -- Fluorescence In-Situ Hybridization. It was developed by Roysam along with Jim Turner, director of the Wadsworth's Nanobiotechnology Program, and a team of scientists led by Carol Barnes, research scientist and professor of psychology and neurology at the University of Arizona.

"This is a powerful tool for large-scale and quantitative testing of biological hypotheses, especially when combined with related technologies developed at Rensselaer," says Roysam. "It can be used in many other areas of cell and molecular research."

The technology is currently being used to test hypotheses on the behavior of neurons grown over engineered surfaces, the development of tumor blood vessels, and the effects of polychlorinated biphenyls (PCBs) on river life forms.

Barnes says the software has proven to be a helpful tool in her team's studies of whether cognitive tasks trigger specific gene reactions. "We have made great progress over the last couple of years, and we couldn't have done it without RPI's image analysis technology," says Barnes.


Story Source:

The above story is based on materials provided by Rensselaer Polytechnic Institute. Note: Materials may be edited for content and length.


Cite This Page:

Rensselaer Polytechnic Institute. "Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When." ScienceDaily. ScienceDaily, 10 February 2003. <www.sciencedaily.com/releases/2003/02/030210075428.htm>.
Rensselaer Polytechnic Institute. (2003, February 10). Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2003/02/030210075428.htm
Rensselaer Polytechnic Institute. "Computer Automation Software Speeds Brain Research; Tool Sheds Light On Which Specific Brain Cells Are Active And When." ScienceDaily. www.sciencedaily.com/releases/2003/02/030210075428.htm (accessed September 17, 2014).

Share This



More Mind & Brain News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins