Featured Research

from universities, journals, and other organizations

High Estrogen/Progestin Levels May Reduce Asthma Severity, Say Pittsburgh Researchers

Date:
March 20, 2003
Source:
University Of Pittsburgh Medical Center
Summary:
Progesterone and estrogen appear to have a positive effect on lung function and reduce the symptoms of asthma, according to a report published by University of Pittsburgh Graduate School of Public Health researchers.

PITTSBURGH, March 19 – Progesterone and estrogen appear to have a positive effect on lung function and reduce the symptoms of asthma, according to a report published by University of Pittsburgh Graduate School of Public Health (GSPH) researchers in the March issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology.

"We found that women's lung function and asthma symptoms improve when estrogen and progesterone levels are raised, both naturally during certain times in the menstrual cycle and with the administration of oral contraceptives or hormone replacement therapy," said Catherine L. Haggerty, Ph.D., M.P.H., GSPH post-doctoral fellow and senior author of the report. "These studies suggest that estrogen and progesterone play a role in strengthening respiratory muscle and in increasing relaxation of bronchial smooth muscle, thereby reducing the contractile response. The two hormones also have been shown to exhibit anti-inflammatory properties."

Dr. Haggerty and her colleagues reviewed scientific data generated between 1966 and 2001 and discovered that asthmatic patients experienced increased asthma episodes, increased hospitalizations for asthma and decreased pulmonary function during the premenstrual and menstrual phase, when hormonal levels are low. Conversely, some women experience improved pulmonary function and a decrease in asthma exacerbation while taking oral contraceptives and hormone replacement therapy.

"Estrogen and progesterone are highly elevated during pregnancy, reaching their greatest concentrations during the final trimester. In some women, improvements in asthma symptoms from preconception to pregnancy parallel these changes in hormonal levels, with the lowest rate of symptoms occurring during the last four weeks," Dr. Haggerty said.

According to the authors, certain subgroups of women may be more susceptible to hormone cycles. Testosterone, estrogen and progesterone may each independently affect pulmonary function to varying degrees.

"A further understanding of the role of hormones in asthma may better predict exacerbations and direct therapeutic strategies. Such an understanding may help to improve the quality of life in women who suffer from this often-debilitating disease," said Dr. Haggerty.


Story Source:

The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pittsburgh Medical Center. "High Estrogen/Progestin Levels May Reduce Asthma Severity, Say Pittsburgh Researchers." ScienceDaily. ScienceDaily, 20 March 2003. <www.sciencedaily.com/releases/2003/03/030320074001.htm>.
University Of Pittsburgh Medical Center. (2003, March 20). High Estrogen/Progestin Levels May Reduce Asthma Severity, Say Pittsburgh Researchers. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2003/03/030320074001.htm
University Of Pittsburgh Medical Center. "High Estrogen/Progestin Levels May Reduce Asthma Severity, Say Pittsburgh Researchers." ScienceDaily. www.sciencedaily.com/releases/2003/03/030320074001.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins