Featured Research

from universities, journals, and other organizations

Rush Testing Kinder, Gentler Therapy For Lung Cancer

Date:
May 23, 2003
Source:
Rush Presbyterian St. Luke's Medical Center
Summary:
Oncologists at Rush-Presbyterian-St. Luke's Medical Center have begun testing a new medication that seeks to improve lung cancer treatment, reduce chemotherapy's common side effects and decrease infusion time from one hour to about 15 minutes.

CHICAGO -- Oncologists at Rush-Presbyterian-St. Luke's Medical Center have begun testing a new medication that seeks to improve lung cancer treatment, reduce chemotherapy's common side effects and decrease infusion time from one hour to about 15 minutes.

Related Articles


The medication being studied is called Xyotax, which links paclitaxel, a commonly used chemotherapuetic agent, to a biogradeable polymer. This polymer creates a new chemical, designed to deliver higher and potentially more effective levels of paclitaxel to tumors.

Paclitaxel is one of the families of chemotherapy agents known as taxanes, the most widely used anticancer drugs in the treatment of non-small cell lung, breast, ovarian, and prostate cancers. Patients with non-small cell lung cancer who qualify for this Phase III study will receive either Xyotax, or another therapy called docetaxel.

"It is a kinder, gentler treatment for lung cancer," said Dr. Philip Bonomi, director of the Rush section of Oncology and Hematology and the only Chicago investigator in this study. "Xyotax offers patients convenience, shorter time spent in doctors' offices, and I believe it will be less toxic."

Unlike blood vessels in healthy tissue, those in tumor tissues have openings that make them porous to large molecules. Xyotax flows through healthy blood vessels and because the chemotherapy is inactive when bound to the polymer, lower levels of the drug are seen in the bloodstream. However, in tumor blood vessels, Xyotax leaks through the pores and is trapped in tumor tissue.

Xyotax is taken up by tumor cells through a process called pinocytosis. Because the polymer is made up of biodigestible amino acids, it is metabolized inside the tumor, releasing the paclitexal. This allows Xyotax to bypass a primary mechanism by which tumor cells grow resistant. The result is that Xyotax should work better and be potentially safer than many existing chemotherapy agents.

Bonomi said that because this is a Phase III study, it is unclear just how well patients who take Xyotax will do. Bonomi believes that even if this drug shows a small improvement, the decreased side effects -- nausea, hair loss and fatigue -- it still might make Xyotax an attractive alternative to other chemotherapy agents if it gets Food and Drug Administration approval for widespread use.

Lung cancer is the leading cancer killer in both men and women. There were an estimated 156,900 deaths from lung cancer in the United States in 2000 and non small cell lung cancer deaths account for 85 percent of the 164,000 news cases of lung cancer that develop each year.

###

Rush-Presbyterian-St. Luke's Medical Center is an academic medical center that encompasses the 824-bed Presbyterian-St. Luke's Hospital (including Rush Children's Hospital), the 110-bed Johnston R. Bowman Health Center and Rush University. Rush University, with more than 1,270 students, is home to one of the first medical schools in the Midwest, one of the nation's top-ranked nursing colleges, as well as graduate programs in allied health and the basic sciences. Rush is noted for bringing together clinical care and research to address major health problems, including arthritis and orthopedic disorders, cancer, heart disease, mental illness neurological disorders and diseases associated with aging.


Story Source:

The above story is based on materials provided by Rush Presbyterian St. Luke's Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Rush Presbyterian St. Luke's Medical Center. "Rush Testing Kinder, Gentler Therapy For Lung Cancer." ScienceDaily. ScienceDaily, 23 May 2003. <www.sciencedaily.com/releases/2003/05/030523080425.htm>.
Rush Presbyterian St. Luke's Medical Center. (2003, May 23). Rush Testing Kinder, Gentler Therapy For Lung Cancer. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2003/05/030523080425.htm
Rush Presbyterian St. Luke's Medical Center. "Rush Testing Kinder, Gentler Therapy For Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2003/05/030523080425.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins