Featured Research

from universities, journals, and other organizations

Stem Cells Isolated From Monkey Eggs Continue Producing Variety Of Other Cells

Date:
September 23, 2003
Source:
Wake Forest University Baptist Medical Center
Summary:
A line of monkey stem cells, produced without the use of an embryo, has reproduced for more than two years and still retains the capability of differentiating into a variety of tissue types, a research team reports in the current on-line edition of the Proceedings of the National Academy of Sciences.

WINSTON-SALEM, N.C. - A line of monkey stem cells, produced without the use of an embryo, has reproduced for more than two years and still retains the capability of differentiating into a variety of tissue types, a research team reports in the current on-line edition of the Proceedings of the National Academy of Sciences.

Kent Vrana, Ph.D., professor of physiology and pharmacology at Wake Forest University Baptist Medical Center and the first author on the report, said the stem cells have produced two types of neurons, and many other tissues such as heart, smooth muscle and beating cilia, the tiny hairlike extensions that line the airways.

The research team, from four universities and two private companies, first reported the stem cell line in January 2002 in the journal Science. At that time, some other scientists thought that the stem cell line might stop after several generations.

Vrana reports in the current paper that the stem cells possess the biological properties of indefinite replication found in cancer cells and embryonic stem cells.

These stem cells were developed by a process called parthenogenesis -- using only an egg from a female monkey and no sperm. The resulting multiplying group of cells, called a parthenote, cannot successfully implant into the mother's womb and hence cannot develop any further than what is called the blastocyst stage, essentially a ball of cells.

But the team was able to take cells from that blastocyst and begin the stem cell line, called Cyno-1. Jason Hipp, a Wake Forest graduate student and second author on the paper, said this approach could "bypass the need for creating a competent embryo for the creation of stem cells."

Of great interest is the potential for developing an unlimited number of one type of neuron. These neurons could eventually pave the way for the treatment of Parkinson's disease.

The neurons synthesize a neurotransmitter called dopamine, and are impaired in people with Parkinson's disease.

"Clinical transplantation of specific fetal neurons has shown promise in the treatment of Parkinson's and Huntington's disease," said Vrana, "but obtaining such cells from animals or human fetal brain remains problematic." Obtaining cells produced in the laboratory from stem cells that come from parthenotes "could alleviate some of the ethical and technical concerns of human cell therapy."

Vrana said the striking ability of these stem cells derived from parthenotes to differentiate suggest a valid alternative to stem cells derived from normal fertilization.

To test whether the stem cells were "pluripotent" -- able to produce any cells -- the stem cells were injected into a mouse without a functioning immune system. The cells produced all three of the body's cell layers: ectoderm (neuron, skin and hair follicles), mesoderm (cartilage, muscle and bone) and endoderm (intestinal epithelia), according to Jose Cibelli, professor of animal science at Michigan State University and co-author.

Moreover, the monkey stem cells have a normal number of chromosomes, Vrana said.

Parthenogenesis is not new biologically, but it is unknown in mammals. "Flies, ants, lizards, snakes, birds, reptiles, amphibians, honeybees and crayfish routinely reproduce in this manner. Placental mammals are not capable of this form of reproduction," said Vrana.

Among other members of the team were Ashley Goss, undergraduate student, Kathleen A. Grant, Ph.D., professor, Brian A. McCool, Ph.D., and Stephen J. Walker, Ph.D., assistant professors of physiology and pharmacology, and David Riddle, Ph.D., assistant professor of neurobiology and anatomy, all from Wake Forest; Peter Wettstein from the Department of Microbiology and Immunology at the Mayo Clinic; Lorenz Studer and Viviane Tabor from the Sloan Kettering Cancer Center in New York; Kerrianne Cunniff from Millennium Pharmaceuticals in Cambridge, Mass.; and Michael D. West and other researchers from Advanced Cell Technology in Worcester, Mass.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Stem Cells Isolated From Monkey Eggs Continue Producing Variety Of Other Cells." ScienceDaily. ScienceDaily, 23 September 2003. <www.sciencedaily.com/releases/2003/09/030923065359.htm>.
Wake Forest University Baptist Medical Center. (2003, September 23). Stem Cells Isolated From Monkey Eggs Continue Producing Variety Of Other Cells. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2003/09/030923065359.htm
Wake Forest University Baptist Medical Center. "Stem Cells Isolated From Monkey Eggs Continue Producing Variety Of Other Cells." ScienceDaily. www.sciencedaily.com/releases/2003/09/030923065359.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) — As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) — When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins