Featured Research

from universities, journals, and other organizations

Vitamins Do Little To Prevent Recurrent Stroke

Date:
February 5, 2004
Source:
Wake Forest University Baptist Medical Center
Summary:
A major national study testing whether high-dose vitamins could prevent another stroke found that the vitamins had little effect, according to a report in today's (Feb. 4) issue of the Journal of the American Medical Association.

WINSTON-SALEM, N.C. – A major national study testing whether high-dose vitamins could prevent another stroke found that the vitamins had little effect, according to a report in today's (Feb. 4) issue of the Journal of the American Medical Association.

Related Articles


The study, led by James F. Toole, M.D., professor of neurology and director of the Stroke Research Center at Wake Forest University Baptist Medical Center, found nearly identical rates of recurrent strokes and heart attacks between participants on a high dose of folic acid, B6, and B12 vitamins and those taking a low dose.

"High-dose vitamin therapy had no effect on stroke prevention, coronary heart disease events or death in this study, which was disappointing," Toole said.

The study, called VISP (for Vitamin Intervention for Stroke Prevention), involved 3,680 adults who had already had a non-disabling stroke and were being treated at one of 56 centers in the United States, Canada and Scotland. Half of the patients were assigned to the high dose group and half to the low dose.

Neither the patients nor their doctors knew which group they were in. The daily vitamin pills were identical in outward appearance.

During the study, 8.1 percent of patients on the low vitamin dose and 8.4 percent of patients on the high dose had a second stroke, which statistically is nearly identical.

The study found that the vitamin therapy lowered levels of homocysteine – an amino acid – leading the investigators to say, "Findings in other trials of an association between total homocysteine with increased risk of stroke and heart disease suggests that longer trials in different populations with elevated total homocysteine may be necessary."

The study did show that in both the low dose and in the high dose vitamin group those with a high homocysteine level at the start of the study were the most likely to have a recurrent stroke.

Of patients in the low-dose or control group, 6.7 percent had a coronary heart disease "event," usually a heart attack, compared to 6.3 percent of patients on the high dose. Overall deaths from any cause totaled 5.4 percent of the high-dose group compared to 6.3 percent of the low-dose group.

Just after the start of VISP, folate fortification of the U.S. grain supply began (which increased folic acid in breads and other foods containing grains) and it became mandatory in January 1998. This "profoundly reduced" the number of people with low levels of folate and high total homocysteine levels, Toole said.

The study was stopped in December 2002, when the study's performance and safety monitoring board told the funding agency, the National Institute of Neurological Disorders and Stroke, that "there was no chance of showing any difference between the two treatment groups during the remaining follow-up period."


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Vitamins Do Little To Prevent Recurrent Stroke." ScienceDaily. ScienceDaily, 5 February 2004. <www.sciencedaily.com/releases/2004/02/040203235857.htm>.
Wake Forest University Baptist Medical Center. (2004, February 5). Vitamins Do Little To Prevent Recurrent Stroke. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2004/02/040203235857.htm
Wake Forest University Baptist Medical Center. "Vitamins Do Little To Prevent Recurrent Stroke." ScienceDaily. www.sciencedaily.com/releases/2004/02/040203235857.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins