Featured Research

from universities, journals, and other organizations

Improving Treatment Of Medulloblastoma, A Common Childhood Brain Tumor

Date:
March 4, 2004
Source:
St. Jude Children's Research Hospital
Summary:
A recently completed international pilot study brings researchers closer to an international clinical trial aimed at improving guidelines for treatment of medulloblastoma, a common type of childhood brain cancer.

A recently completed international pilot study brings researchers closer to an international clinical trial aimed at improving guidelines for treatment of medulloblastoma, a common type of childhood brain cancer. A report on this study, from investigators at St. Jude Children's Research Hospital, will appear in the March 15 issue of the Journal of Clinical Oncology (JCO).

Related Articles


The pilot study is the first to demonstrate that medulloblastoma samples can be rapidly delivered to a central research institution and analyzed. The findings confirmed that samples shipped from institutions in the United States and Australia can be analyzed at St. Jude for genetic abnormalities rapidly enough to provide physicians with information to guide their treatment decisions.

The study also demonstrated that by detecting the presence of a protein called ERBB2 in tumor samples, doctors might be able to predict which children with medulloblastoma will require more intensive treatment.

Radiation therapy can cause loss of some normal brain tissue, resulting in a decline in intellectual function and long-term problems with certain hormones, such as thyroid and growth hormones. Therefore, identifying patients who can safely undergo a milder course of treatment can help minimize these lasting effects of therapy.

Ultimately, guiding treatment using knowledge of tumor biology could increase survival rates while reducing the severity of toxic side-effects.

The study was led by Richard Gilbertson, M.D., Ph.D., of St. Jude Department of Developmental Neurobiology, and Amar Gajjar, M.D., in the department of Hematology/Oncology.

"This study paves the way to generate a comprehensive molecular fingerprint of the genetic abnormalities in medulloblastoma," Gilbertson said. "The information will allow us to provide new guidelines for the way we use existing treatments and help us to identify new therapies."

Gajjar elaborated on the need for new treatment guidelines.

"We clearly need new guidelines for judging how an individual child's tumor is going to behave," Gajjar said. "At present we know that 20 to 30 percent of patients thought to have a good chance of getting cured will actually turn out to be resistant to radiation and chemotherapy. We also can't reliably identify the unknown number of patients who are likely to be over-treated because their tumors are actually more sensitive to radiation than we realized."

International studies, to be conducted by the Children's Oncology Group (COG, US) and the International Scoeity of Pediatric Oncology (SIOP, Europe) over the next several years, will prospectively evaluate the survival significance of molecular prognostic markers among children with medulloblastoma.

Other authors of the St. Jude study include Roberto Hernan, Mehmet Kocak, Christine Fuller, Youngsoo Lee, Peter J. McKinnon, Dana Wallace, and Larry Kun (St. Jude); and Ching Lau, Murali Chintagumpala, (Baylor) David Ashley (Royal Children's Hospital, Melbourne), and Steward Kellie (New Children's Hospital, Westmead)

This work was supported by the V-Foundation for Cancer Research, a Cancer Center (CORE) Support Grant and ALSAC.


Story Source:

The above story is based on materials provided by St. Jude Children's Research Hospital. Note: Materials may be edited for content and length.


Cite This Page:

St. Jude Children's Research Hospital. "Improving Treatment Of Medulloblastoma, A Common Childhood Brain Tumor." ScienceDaily. ScienceDaily, 4 March 2004. <www.sciencedaily.com/releases/2004/03/040303074200.htm>.
St. Jude Children's Research Hospital. (2004, March 4). Improving Treatment Of Medulloblastoma, A Common Childhood Brain Tumor. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2004/03/040303074200.htm
St. Jude Children's Research Hospital. "Improving Treatment Of Medulloblastoma, A Common Childhood Brain Tumor." ScienceDaily. www.sciencedaily.com/releases/2004/03/040303074200.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins