Featured Research

from universities, journals, and other organizations

U.S. Researchers Show Cottonseed Drug Is Cancer Treatment Booster

Date:
October 4, 2004
Source:
European Organisation For Research And Treatment Of Cancer
Summary:
New research from the United States has opened up the prospect that gossypol – a drug refined from cottonseed oil and previously tried and abandoned as a male contraceptive – could boost the effectiveness of treatment for prostate tumours and possibly other common cancers as well.

Geneva, Switzerland: New research from the United States has opened up the prospect that gossypol – a drug refined from cottonseed oil and previously tried and abandoned as a male contraceptive – could boost the effectiveness of treatment for prostate tumours and possibly other common cancers as well.

Dr. Liang Xu, a research assistant professor at the University of Michigan, reported today (Friday 1 October) to the EORTC-NCI-AACR[1] Symposium on Molecular Targets and Cancer Therapeutics in Geneva that gossypol has been shown by many groups to have anti-tumour activities.

But his team, under the leadership of Dr Marc Lippman and Dr Shaomeng Wang at the University's Comprehensive Cancer Center, has now demonstrated that a potential small molecule inhibitor of Bcl-2/xL proteins can boost the efficacy of radiotherapy and chemotherapy. They showed that the molecule, (-)-gossypol (minus gossypol)[2], inhibited the anti-apoptotic function of Bcl-2/xL in cells, and increased induction of apoptosis (programmed cell death) and made the tumours more sensitive to radiotherapy in human prostate tumours in mice. The study demonstrates for the first time that (-)-gossypol enhances the anti-tumour efficacy of radiation therapy both in vitro and in vivo with increased induction of apoptosis.

Dr. Xu explained: "The significance of this is that Bcl-2 and Bcl-xL proteins are over expressed in many cancers, making them resistant to drug and radiation treatment. So, it is not just prostate cancer that our findings are relevant to, but also other cancers with BcL-2/xL expression, such as those of the lung, breast, ovary, pancreas, skin, brain and head and neck, where (-)-gossypol may also sensitise cancer cells to chemo/radiotherapy."

He said that based on their cell and animal data the (-)-gossypol form of the drug was likely to be more active than the same doses of natural gossypol used in previous studies. Furthermore, their cell and animal data show that (-)-gossypol would make radiotherapy and chemotherapy more powerful and overcome the resistance to drug and radiation treatment caused by high levels of Bcl-2/xL.

Gossypol was researched as a male contraceptive in China as long ago as 1929 although the results were not published until 1957, but after large scale studies in the 1970s it was abandoned because some men remained infertile after stopping treatment. There were plans in Brazil in the 1990s to market the drug but these were shelved. In 1998 the World Health Organisation said that research on its use for contraception should be abandoned.

Gossypol is not the first drug investigated as a contraceptive to find a potential role in treating cancer.

Tamoxifen was first developed as a female contraceptive and failed, only to become the world's most successful breast cancer drug.

Will gossypol follow in the footsteps of tamoxifen? "There is a lot of research still to do, but we certainly hope so," said Dr. Xu. "The natural form of gossypol has been extensively tested in humans and is well tolerated for long-term use. If we use the more active form, (-)-gossypol, correctly and wisely – for example, in combination with radiation and/or chemotherapy – gossypol may soon find its new role in our fight against cancer."

Dr. Xu wishes to see the findings clinically tested soon and a Phase I trial is planned.


Story Source:

The above story is based on materials provided by European Organisation For Research And Treatment Of Cancer. Note: Materials may be edited for content and length.


Cite This Page:

European Organisation For Research And Treatment Of Cancer. "U.S. Researchers Show Cottonseed Drug Is Cancer Treatment Booster." ScienceDaily. ScienceDaily, 4 October 2004. <www.sciencedaily.com/releases/2004/10/041001091115.htm>.
European Organisation For Research And Treatment Of Cancer. (2004, October 4). U.S. Researchers Show Cottonseed Drug Is Cancer Treatment Booster. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2004/10/041001091115.htm
European Organisation For Research And Treatment Of Cancer. "U.S. Researchers Show Cottonseed Drug Is Cancer Treatment Booster." ScienceDaily. www.sciencedaily.com/releases/2004/10/041001091115.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins