Featured Research

from universities, journals, and other organizations

Novel Drug Therapy For Sleep Apnea

Date:
October 5, 2004
Source:
University Of Illinois At Chicago
Summary:
A promising drug therapy for the treatment of sleep apnea, a serious and common sleep-related breathing disorder has been licensed by the University of Illinois at Chicago, where it was first conceptualized, to an intellectual property and technology commercialization company for clinical development.

A promising drug therapy for the treatment of sleep apnea, a serious and common sleep-related breathing disorder has been licensed by the University of Illinois at Chicago, where it was first conceptualized, to an intellectual property and technology commercialization company for clinical development.

UIC signed a licensing and research agreement to further develop a novel pharmacological therapy for sleep apnea with BTG, of Conshohocken, Pa.

The basis for the therapy was uncovered by two noted UIC sleep researchers, Drs. David Carley and Miodrag Radulovacki, who demonstrated in preclinical and clinical studies that turning up or down the signaling pathways of certain neurotransmitters can significantly reduce the incidence of sleep apnea.

"This has real clinical significance," said Carley, who is professor of medicine, pharmacology and bioengineering and director of research at the UIC Center for Sleep and Ventilatory Disorders. "Although sleep apnea is as common as asthma or diabetes, there is currently no cure and no fully effective long-term treatment."

Sleep apnea is a serious respiratory disorder that involves cessation of breathing for prolonged intervals during sleep. It is estimated that 15-20 million people in the United States suffer from apnea, which has been linked to increased risk for hypertension, heart failure, depression and diabetes.

Currently, no drugs are approved to treat sleep apnea. The novel therapy being developed by BTG and UIC comprises a combination of two drugs that are currently approved and in use to treat conditions unrelated to sleep apnea.

"We believe that safe and effective drug treatments are achievable for sleep apnea, and are delighted to have BTG as a strategic partner in this development program," said Radulovacki, who is professor of pharmacology and medicine.

Under the terms of the agreement, UIC grants BTG specific exclusive rights to intellectual property and inventions related to the development of therapeutic treatment of sleep apnea, as well as rights to new intellectual property developed through a BTG funded research program. The agreement also includes a revenue share arrangement between the parties upon successful product commercialization.

"BTG is very proud to be working with UIC and investigators of Drs. Carley and Radulovacki's stature," said Thomas Logan, vice president of BTG's BioPharmaceuticals business unit. "Based on their groundbreaking laboratory and clinical research we are optimistic that a pharmacological therapeutic option to treat sleep apnea is achievable.

"This investment project is a continuation of a very productive relationship between our institutions and is a lead program in BTG's portfolio of clinical development programs that involve new uses for existing drugs and drug combinations," Logan said.

UIC ranks among the nation's top 50 universities in federal research funding and is Chicago's largest university with 25,000 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "Novel Drug Therapy For Sleep Apnea." ScienceDaily. ScienceDaily, 5 October 2004. <www.sciencedaily.com/releases/2004/10/041005073612.htm>.
University Of Illinois At Chicago. (2004, October 5). Novel Drug Therapy For Sleep Apnea. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2004/10/041005073612.htm
University Of Illinois At Chicago. "Novel Drug Therapy For Sleep Apnea." ScienceDaily. www.sciencedaily.com/releases/2004/10/041005073612.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins