Featured Research

from universities, journals, and other organizations

Study Reports Genetic Susceptibility To Alcoholism In NMDA Receptor

Date:
October 22, 2004
Source:
Yale University
Summary:
Receptors in the brain that are highly sensitive to alcohol may function differently in a person with a family history of alcoholism, according to a Yale study published this month.

Receptors in the brain that are highly sensitive to alcohol may function differently in a person with a family history of alcoholism, according to a Yale study published this month.

Related Articles


The study included 45 healthy subjects, some with a family history of alcoholism and others with no family history. None of the study participants had a drinking problem. All of the participants were administered a placebo or ketamine, an anesthetic that induces alcohol-like effects. Their behavioral responses were then observed. People with a family history of alcoholism were less sensitive to ketamine.

"This study confirms a hypothesis that people with a family history of alcoholism are more vulnerable to alcoholism because they are less likely to get the 'warning signs' of when to stop drinking," said Ismene Petrakis, M.D., associate professor of psychiatry. "In the right environmental and social context, the loss of a potentially important 'brake' on drinking may promote heavy drinking."

The NMDA glutamate receptors, which were the focus in this study, are the highest affinity ethanol targets in the brain. The purpose of the study was to examine whether healthy individuals with a strong family history of alcoholism exhibit alterations in NMDA receptor function.

The Yale research team will next repeat the study to look for genetic variations in reactions to alcohol.

###

Citation: American Journal of Psychiatry, Vol. 161: pp 1776-1782, October 2004


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Study Reports Genetic Susceptibility To Alcoholism In NMDA Receptor." ScienceDaily. ScienceDaily, 22 October 2004. <www.sciencedaily.com/releases/2004/10/041021084120.htm>.
Yale University. (2004, October 22). Study Reports Genetic Susceptibility To Alcoholism In NMDA Receptor. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2004/10/041021084120.htm
Yale University. "Study Reports Genetic Susceptibility To Alcoholism In NMDA Receptor." ScienceDaily. www.sciencedaily.com/releases/2004/10/041021084120.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
You Don't Have To Be Alcohol Dependent To Need Treatment

You Don't Have To Be Alcohol Dependent To Need Treatment

Newsy (Nov. 21, 2014) A study by the Centers for Disease Control and Prevention found 9 out of 10 excessive drinkers in the country are not alcohol dependent. Video provided by Newsy
Powered by NewsLook.com
Your Complicated Job Might Keep Your Brain Young

Your Complicated Job Might Keep Your Brain Young

Newsy (Nov. 20, 2014) Researchers at the University of Edinburgh found the more complex your job is, the sharper your cognitive skills will likely be as you age. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins