Featured Research

from universities, journals, and other organizations

Prevention Of Prostate Cancer, Osteoporosis In Men Under Study

Date:
October 28, 2004
Source:
Medical College Of Georgia
Summary:
Preventing prostate cancer and helping men with the disease avoid osteoporosis is the focus of two new clinical trials at the Medical College of Georgia.

Dr. James A. Brown, Medical College of Georgia urologist specializing in prostate cancer, and Mary Anne Park, director of the MCG Surgical Research Service, are looking at treatments to prevent prostate cancer and prevent osteoporosis in men who have the disease.
Credit: Photo courtesy of Medical College Of Georgia

Preventing prostate cancer and helping men with the disease avoid osteoporosis is the focus of two new clinical trials at the Medical College of Georgia.

Related Articles


MCG is participating in a national study to determine whether men can reduce their prostate cancer risk by taking a drug that halts the conversion of the male hormone to a super-duper hormone that appears to stimulate prostate cancer growth.

The lifetime risk of prostate cancer is about 1 in 6 for American men, except for blacks as well as men with a family history who are at increased risk, according to the National Prostate Cancer Coalition; the risk increases to about 50 percent by age 80.

MCG also is a study site for a national study looking at whether a new drug that slows bone resorption can help prostate cancer patients avoid osteoporosis.

The cancer prevention study examines the potential of dutasteride, the active ingredient in a drug marketed to treat prostate enlargement, a common problem of aging.

“While there is no direct relationship between prostate enlargement and prostate cancer, both cancerous and benign growth of the prostate appear to be stimulated by this super hormone called dihydrotestosterone,” says Dr. James A. Brown, MCG urologist specializing in prostate cancer. For some unknown reason, circulating male hormone, testosterone, is converted into this more potent male hormone in the prostate gland and scalp. “What is neat about that is if you can prevent that conversion … you are taking away a potent stimulator of cell growth,” says the Georgia Cancer Coalition Distinguished Cancer Clinician and Scientist. “Many of the cells in the gland will atrophy and shrink away.”

For the prevention study, MCG is evaluating patients age 50-75 with elevated PSAs, a marker for prostate cancer, who have had a negative biopsy in the last six months. The study runs for four years and participants will receive additional biopsies at years two and four.

The osteoporosis prevention study looks at the bone-thinning disease often associated with menopausal women. Loss of the female hormone, estrogen, helps disrupt the normal balance between cells called osteoblasts that make bone and osteoclasts that consume it. While men also naturally experience a decline in their testosterone level with age, they keep making the hormone throughout life and tend to start out with denser bones than women, unless they get prostate cancer. Much like breast cancer, prostate cancer is a hormone-dependent cancer and a mainstay of treatment is hormone therapy. “Testicles make male hormone,” says Dr. Brown. “The prostate gland is a sex organ that responds to male hormone. This gland develops at puberty, with the influx of hormones, but it will often continue to grow throughout life, which is why sometimes with age, men have problems with an enlarged prostate. Cancer also will grow more rapidly and aggressively with male hormone circulating.”

Men often prefer that the testicles that produce male hormones not be surgically removed. The alternative is therapy that suppresses hormone production, essentially chemical castration to prevent signaling the testes to make hormone. “The mainstay of prostate cancer therapy is anti-hormone therapy and men typically are on it for years,” says Dr. Brown. Side effects often include markedly reduced libido as well as the increased risk of osteoporosis.

The study looks as a new bisphosphonate that slows bone resorption and may help correct the bone deficit that occurs with anti-hormone therapy, Dr. Brown says. For the study, MCG is looking for men with prostate cancer who are taking anti-hormone therapy for their disease. Participants will be followed for two years; half will receive the study drug and half will receive placebo. MCG expects to enroll about 20 patients in the study that will follow 1,200 men nationally.

Dr. Brown notes that in addition to new therapies still under evaluation, new treatment approaches already being used, such as laparoscopic and robotic surgery, are reducing the trauma and side effects of surgically removing a diseased prostate. The standard approach to removal has been about a six-inch vertical incision from the navel downward. Side effects include lost ability for a spontaneous erection and prolonged problems with incontinence. With five small incisions instead of one big one, the laparoscopic approach cuts post-surgical pain and recovery time. Less nerve damage also means men often regain continence more quickly and the minimally invasive approach appears to reduce the risk of ongoing erectile dysfunction, Dr. Brown says.


Story Source:

The above story is based on materials provided by Medical College Of Georgia. Note: Materials may be edited for content and length.


Cite This Page:

Medical College Of Georgia. "Prevention Of Prostate Cancer, Osteoporosis In Men Under Study." ScienceDaily. ScienceDaily, 28 October 2004. <www.sciencedaily.com/releases/2004/10/041027114135.htm>.
Medical College Of Georgia. (2004, October 28). Prevention Of Prostate Cancer, Osteoporosis In Men Under Study. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2004/10/041027114135.htm
Medical College Of Georgia. "Prevention Of Prostate Cancer, Osteoporosis In Men Under Study." ScienceDaily. www.sciencedaily.com/releases/2004/10/041027114135.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins