Featured Research

from universities, journals, and other organizations

Genes Tied To Abnormal Immune Response In Mice With Lupus

Date:
December 30, 2004
Source:
Cell Press
Summary:
Scientists have uncovered a link between a family of genes and abnormalities of the immune system that are associated with systemic lupus erythematosus (SLE), a devastating disease that affects over 1 million Americans.

Scientists have uncovered a link between a family of genes and abnormalities of the immune system that are associated with systemic lupus erythematosus (SLE), a devastating disease that affects over 1 million Americans. The research, published in the December issue of Immunity, significantly advances the understanding of the pathology of lupus-like autoimmunity in mice and may facilitate the design of future therapies for lupus in humans.

A normal immune system protects the body against viruses, bacteria and other potentially harmful foreign invaders. In an autoimmune disease, like SLE, the immune system loses its ability to tell the difference between foreign substances that pose a threat and the cells of the body. In SLE, the immune system attacks and damages the body's own tissues and organs, including the joints, kidneys, heart, lungs, brain, blood and skin. Dr. Edward K. Wakeland from the University of Texas Southwestern Medical Center and colleagues used a lupus-prone mouse model of SLE to characterize genes directly involved with SLE susceptibility.

The researchers report that variations in the structure and expression of a subset of genes belonging to the SLAM/CD2 family may contribute to autoimmunity in mice with lupus. Scientists have known for some time that SLAM/CD2 genes play a critical role in controlling immune cells and responses. Evidence presented here suggests that the altered SLAM/CD2 members may be responsible for abnormal lymphocyte responses. The Ly108 gene, which is expressed at elevated levels in lymphocytes from lupus susceptible mice, has emerged as a likely contributor to abnormal immune activation. However, Ly108 and other SLAM/CD2 genes are thought to act in combination with additional genes and signaling molecules in these mice and further research is needed to identify the specific interactions that lead to an overzealous immune response.

The researchers conclude that sequence and expression level differences in a subset of SLAM/CD2 genes are associated with the autoimmune response observed in SLE mice. "Given our association of variations in the SLAM/CD2 cluster with lupus susceptibility in mice, further work on the relationship of polymorphisms in the SLAM/CD2 cluster to SLE in humans is clearly warranted," says Dr. Wakeland.

###

Amy E. Wandstrat, Charles Nguyen, Nisha Limaye, Alice Y. Chan, Srividya Subramanian, Xiang-Hong Tian, Young-Sun Yim, Alexander Pertsemlidis, Harold R. Garner, Jr., Laurence Morel, and Edward K. Wakeland: "Association of Extensive Polymorphisms in the SLAM/CD2 Gene Cluster with Murine Lupus"

Publishing in Immunity, Volume 21, Number 6, December 2004, pages 769–780. http://www.immunity.com

The other members of the research team include Amy E. Wandstrat, Charles Nguyen, Nisha Limaye, Alice Y. Chan, Srividya Subramanian, Xiang-Hong Tian, Alexander Pertsemlidis, and Harold R. Garner, Jr. of University of Texas Southwestern Medical Center; Young-Sun Yim of the University of Missouri; and Laurence Morel of the University of Florida School of Medicine.

This work was supported by grants from the National Institutes of Health (NIH), The Alliance for Lupus Research, The Lupus Research Institute, and the Arthritis Foundation (E.K.W.). A.E.W. was supported by an NIH postdoctoral fellowship and by a grant from the Lupus Foundation. N.L. was supported in part by a grant from the National Institute of Allergy and Infectious Disease, T32AI005284.

The context and implications of this work are discussed in a Preview by Linda S. Wicker and Laurence B. Peterson.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Genes Tied To Abnormal Immune Response In Mice With Lupus." ScienceDaily. ScienceDaily, 30 December 2004. <www.sciencedaily.com/releases/2004/12/041220004137.htm>.
Cell Press. (2004, December 30). Genes Tied To Abnormal Immune Response In Mice With Lupus. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2004/12/041220004137.htm
Cell Press. "Genes Tied To Abnormal Immune Response In Mice With Lupus." ScienceDaily. www.sciencedaily.com/releases/2004/12/041220004137.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins