Featured Research

from universities, journals, and other organizations

New Protein Holds Promise For Use In Medicine And Nanoscience

Date:
January 7, 2005
Source:
Hebrew University Of Jerusalem
Summary:
Researchers at the Hebrew University of Jerusalem have succeeded in discovering and isolating a new protein from the poplar tree with special structural and qualitative characteristics that could have consequences for development of future nanocapsules for drug delivery to cancer cells.

Bagel-shaped SP-1 protein.
Credit: Image courtesy of Hebrew University Of Jerusalem

Jerusalem, January 6, 2005 – Researchers at the Hebrew University of Jerusalem have succeeded in discovering and isolating a new protein from the poplar tree with special structural and qualitative characteristics that could have consequences for development of future nanocapsules for drug delivery to cancer cells.

In addition to being obtained from plant tissue, the protein can now also be produced in large quantities as a recombinant protein in bacteria, making it highly available for medicinal or other applications.

Called SP-1, the protein has a nanometric, “bagel-shaped,” circular form and is extremely stable. It has been found to be capable of surviving contact with enzymes that break down proteins or exposure to extreme conditions such as boiling, excessive acidity, salinity, organic solvents or detergent solutions.

The research was conducted at the Hebrew University’s Faculty of Agricultural, Food and Environmental Quality Sciences in Rehovot by Prof. Arie Altman, head of the faculty’s Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, and Prof. Oded Shoseyov, with the participation of Dr. Wangxia Wang and Dr. Dan Pelah and the scientists of Fulcrum SP Ltd.: Dr. Amnon Wolf, Dr. Ira Marton and Dr. Yehonathan Pouny.

According to Profs. Altman and Shoseyov, the SP-1 protein serves to assist in creating a properly folded and functioning structure of other proteins within the plant’s cells. The SP-1 also has the ability to assemble itself into a structure composed of 12 identical units, making it exceptionally resistant to extreme conditions. These qualities are rarely found among proteins and make the SP-1 a promising candidate for a multiplicity of uses in developing medicinal applications in the rapidly growing field of nanobiotechnology.

SP-1 nanocapsules will be capable of delivering cell-destroying drugs specifically to certain types of solid cancer tumors. The protein’s tiny structure enables this carrier to penetrate specifically into tumors without harming healthy tissue and thus enhance the effectiveness of chemotherapy. This selective penetration is based on the fact that the blood vessels which feed tumors are considerably more porous than those reaching healthy cells. Therefore, the units of SP-1 carrying the drug would invade only the tumor-feeding blood vessels and not normal ones.

More recently, the three-dimensional structure of the protein was deciphered by x-ray crystallography in the laboratory of Dr. Orna Almog of Ben-Gurion University of the Negev. The research on this was published in the Journal of Biological Chemistry issue of December 2004, authored by Or Dgany of the Hebrew University, Ana Gonzales of Stanford University, Oshrat Sofer of Ben-Gurion University, Wangxia Wang of the Hebrew University, Gennady Zolotnitsky of the Technion, Amnon Wolf of Fulcrum, Yuval Shoham of the Technion, Arie Altman of the Hebrew Univesity, Sharon G. Wolf of the Weizmann Institute, Oded Shoseyov of the Hebrew University and Orna Almog of Ben-Gurion University.

Prof. Altman and Prof. Shoseyov are the scientific founders of the biotech start-up company Fulcrum SP Ltd. that is developing the SP-1 protein for cancer drug delivery and other applications.


Story Source:

The above story is based on materials provided by Hebrew University Of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University Of Jerusalem. "New Protein Holds Promise For Use In Medicine And Nanoscience." ScienceDaily. ScienceDaily, 7 January 2005. <www.sciencedaily.com/releases/2005/01/050106105707.htm>.
Hebrew University Of Jerusalem. (2005, January 7). New Protein Holds Promise For Use In Medicine And Nanoscience. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/01/050106105707.htm
Hebrew University Of Jerusalem. "New Protein Holds Promise For Use In Medicine And Nanoscience." ScienceDaily. www.sciencedaily.com/releases/2005/01/050106105707.htm (accessed July 23, 2014).

Share This




More Matter & Energy News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Robot Parking Valet Creates Stress-Free Travel

Robot Parking Valet Creates Stress-Free Travel

AP (July 23, 2014) 'Ray' the robotic parking valet at Dusseldorf Airport in Germany lets travelers to avoid the hassle of finding a parking spot before heading to the check-in desk. (July 23) Video provided by AP
Powered by NewsLook.com
Boeing Ups Outlook on 52% Profit Jump

Boeing Ups Outlook on 52% Profit Jump

Reuters - Business Video Online (July 23, 2014) Commercial aircraft deliveries rose seven percent at Boeing, prompting the aerospace company to boost full-year profit guidance- though quarterly revenues missed analyst estimates. Bobbi Rebell reports. Video provided by Reuters
Powered by NewsLook.com
Europe's Car Market on the Rebound?

Europe's Car Market on the Rebound?

Reuters - Business Video Online (July 23, 2014) Daimler kicks off a round of second-quarter earnings results from Europe's top carmakers with a healthy set of numbers - prompting hopes that stronger sales in Europe will counter weakness in emerging markets. Hayley Platt reports. Video provided by Reuters
Powered by NewsLook.com
9/11 Commission Members Warn of Terror "fatigue" Among American Public

9/11 Commission Members Warn of Terror "fatigue" Among American Public

Reuters - US Online Video (July 22, 2014) Ten years after releasing its initial report, members of the 9/11 Commission warn of the "waning sense of urgency" in combating terrorists attacks. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins