Featured Research

from universities, journals, and other organizations

Common Virus Becomes A New Target For Cancer Treatment

Date:
March 7, 2005
Source:
American Society Of Hematology
Summary:
A typically innocuous virus found in 90 percent of people worldwide is the key to a new treatment for a cancer particularly common in North Africa and Southeast Asia. A new study showing that antigens produced by the Epstein Barr virus may provide an ideal target for therapy will be published in the March 1, 2005, issue of Blood, the official journal of the American Society of Hematology.

WASHINGTON (February 16, 2005) – A typically innocuous virus found in 90 percent of people worldwide is the key to a new treatment for a cancer particularly common in North Africa and Southeast Asia. A new study showing that antigens produced by the Epstein Barr virus may provide an ideal target for therapy will be published in the March 1, 2005, issue of Blood, the official journal of the American Society of Hematology.

Ten patients diagnosed with advanced nasopharyngeal carcinoma took part in the study – these patients also tested positive for the Epstein Barr virus, a member of the herpes family responsible for the "kissing disease" (mononucleosis) and commonly associated with this cancer's tumors.

Patients were given intravenous doses of specialized T cells that specifically targeted antigens produced by the Epstein Barr virus. Developed by researchers from the Center for Cell and Gene Therapy at Baylor College of Medicine, Methodist Hospital in Houston, and Texas Children's Hospital, these T cells were created using the patient's own blood to recognize the antigens and destroy the cancerous cells harboring the virus. The treatment was well tolerated in all but one patient, who had pre-existing facial swelling that increased after the infusion.

"Radiation and chemotherapy, the traditional treatments for nasopharyngeal carcinoma, frequently fail and can cause severe long-term side effects," said senior study author Helen Heslop, M.D., Professor of Medicine and Pediatrics at Baylor College of Medicine. "There is a compelling need for therapies that can improve disease-free survival without severe toxicity. This study demonstrates that virus-specific T cells show remarkable activity in some patients with this cancer and this may lead to new treatments for nasopharyngeal carcinoma."

A majority of the patients (six) remain completely disease-free one to two years after the treatment. Two patients had no response to the treatment. One patient's cancer progressed after the infusion, which required the addition of chemotherapy. However, the patient experienced a partial remission, whereas previous chemotherapy treatments alone had had no effect. The tenth patient's disease did not better or worsen, but remained stable after treatment.

"This very important work combines the use of a novel target – the antigen produced by the Epstein Barr virus – with the use of cells directed at that protein," notes Donald M. Miller, M.D., Ph.D., Director of the James Graham Brown Cancer Center in Louisville, Kentucky. "The authors provide considerable hope that this approach will realize the important potential of cell-based therapies."

###

This work was supported by the Ter Meulen Fund, the Dutch Cancer Society and the Ank van Vlissingen Foundation (KCM), the GCRC at Baylor College of Medicine (RR00188), the Methodist Foundation, and a Doris Duke Distinguished Clinical Scientist Award (HEH).


Story Source:

The above story is based on materials provided by American Society Of Hematology. Note: Materials may be edited for content and length.


Cite This Page:

American Society Of Hematology. "Common Virus Becomes A New Target For Cancer Treatment." ScienceDaily. ScienceDaily, 7 March 2005. <www.sciencedaily.com/releases/2005/02/050223131140.htm>.
American Society Of Hematology. (2005, March 7). Common Virus Becomes A New Target For Cancer Treatment. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2005/02/050223131140.htm
American Society Of Hematology. "Common Virus Becomes A New Target For Cancer Treatment." ScienceDaily. www.sciencedaily.com/releases/2005/02/050223131140.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins