Featured Research

from universities, journals, and other organizations

Birth Weight And Breastfeeding In Infancy May Affect Premenopausal Breast Cancer Risk

Date:
May 21, 2005
Source:
University At Buffalo
Summary:
Premenopausal women who were heavier than average at birth or had not been breastfed as infants appear to be at increased risk for developing breast cancer, epidemiologists at the University at Buffalo's School of Public health and Health Professions have found.

BUFFALO, N.Y. -- Premenopausal women who were heavier than average at birth or had not been breastfed as infants appear to be at increased risk for developing breast cancer, epidemiologists at the University at Buffalo's School of Public health and Health Professions have found.

Results of the study, which showed no association between birth weight and breastfeeding in infancy and postmenopausal breast-cancer risk, were reported at the American Association for Cancer Research annual meeting in Anaheim, Calif.

"The intrauterine and neonatal life periods have been suggested as critical windows in mammary gland development," said Maddalena Barba, M.D., research instructor in the UB Department of Social and Preventive Medicine and lead researcher on the study.

"In utero and early childhood exposures might affect breast cancer risk by altering the hormonal environment of the developing fetus and young infant through mechanisms not yet completely clarified."

Barba and colleagues from UB's School of Public Health and Health Professions analyzed data collected from 2,382 women participating in the Western New York Exposures and Breast Cancer Study conducted from 1996-2001 during in-person, computer-assisted interviews. Complete information on the exposures of interest was available for 845 participants newly diagnosed with breast cancer during the study period who served as cases, and for 1,573 matched controls.

Researchers compared cases and controls, taking into consideration already well-recognized breast-cancer risk factors such as age, education, body-mass index, history of benign breast disease, family history of cancer, months of lactation, age at first menstrual period, age at first pregnancy, number of pregnancies and age at menopause for postmenopausal women.

Results showed that premenopausal women whose birth weight was greater than 8.5 pounds, and premenopausal women who had not been breast fed as infants, had an almost two-fold risk of developing breast cancer when compared to premenopausal women whose weight at birth was 5.5-7 pounds (reference category) and who had been breast fed.

None of these variables showed a relationship with postmenopausal breast cancer. Birth order was not associated with breast cancer risk in pre- or postmenopausal women.

"Our results support the hypothesis that early life events impact women's breast-cancer risk later in life," said Barba. "Further research based on targeted studies is needed to reach a deeper understanding of the underlying biological mechanisms."

Additional researchers on the study were Susan E. McCann, Ph.D., Jing Nie, Ph.D., Saverio Stranges, M.D., Ph.D., Barbara Fuhrman, Maurizio Trevisan, M.D., and Jo L. Freudenheim, Ph.D., from the Department of Social and Preventive Medicine, and Paola Muti, M.D., formerly at UB, currently at the Italian National Cancer Institute Regina Elena in Rome, Italy.

The research was supported in part by grants from the U.S. Army and the American-Italian Cancer Foundation.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Birth Weight And Breastfeeding In Infancy May Affect Premenopausal Breast Cancer Risk." ScienceDaily. ScienceDaily, 21 May 2005. <www.sciencedaily.com/releases/2005/05/050520175105.htm>.
University At Buffalo. (2005, May 21). Birth Weight And Breastfeeding In Infancy May Affect Premenopausal Breast Cancer Risk. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2005/05/050520175105.htm
University At Buffalo. "Birth Weight And Breastfeeding In Infancy May Affect Premenopausal Breast Cancer Risk." ScienceDaily. www.sciencedaily.com/releases/2005/05/050520175105.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins