Featured Research

from universities, journals, and other organizations

Researchers Discover Molecule That Causes Secondary Stroke

Date:
June 1, 2005
Source:
University Of Cincinnati
Summary:
Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm.

CINCINNATI -- Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm.

A constriction of the blood vessels in the brain, cerebral vasospasm usually occurs three to 10 days following a massive brain bleed known as hemorrhagic stroke. Sixty percent of patients who survive the initial stroke develop vasospasm, and 40 percent of them die from it.

Vasospasm, says neurology department researcher Joseph Clark, PhD, results from a buildup of toxins caused by bleeding from the initial stroke. "Normally the cerebral spinal fluid that envelopes the brain carries off wastes and exchanges them for nutrients at what's called the blood-brain barrier," Dr. Clark says. "After a hemorrhagic stroke, however, toxins given off by the brain bleed contribute to the development of specific molecules that later causes the constricting vasospasm." A research team led by Dr. Clark has now identified the molecules that trigger vasospasm, a breakthrough, he says, that "raises hopes of developing not only new ways to treat the condition, but also a diagnostic test to determine which hemorrhagic stroke survivors are at greater risk."

Several spinal fluid components were suspected of causing the vasospasm, Dr. Clark explains. They included hemoglobin, bilirubin and peroxidized lipids, and a group of bilirubin oxidation products that the researchers called BOXes.

Building on Dr. Clark's earlier studies in rats, the team measured each of the suspect agents in 12 hemorrhagic stroke patients. Within 10 days, four of the group suffered a secondary cerebral vasospasm. The same patients were also found to have elevated levels of bilirubin and significantly higher levels of BOXes.

One of the 12 who had elevated bilirubin, but hardly any BOXes, did not experience a secondary stroke.

When bilirubin is elevated, says team member Gail Pyne-Geithman, PhD, it must be exposed to powerful oxidizers that cause the production of significant amounts of the BOXes. The correlation between elevated BOXes, bilirubin and oxidative stress in this study, she says, was "striking."

The researchers point out that although their findings are encouraging in terms of developing a diagnostic test and treatment, the number of patients in their study was small and more work is needed to confirm that vasospasm is more likely to occur in bleeding-stroke patients who have elevated levels of BOXes.

###

The study is reported in the March 23, 2005 online edition of the Journal of Cerebral Blood Flow and Metabolism. It was funded by The National Institutes of Health and The Neuroscience Institute in Cincinnati. The university, in partnership with the Health Alliance of Greater Cincinnati, established The Neuroscience Institute in 1998 as part of an effort to build upon its national reputation for excellence in neuroscience. The institute includes or is developing research centers that focus on the main diseases of the brain and nerves such as stroke, brain tumors, brain trauma, Parkinson's, Alzheimer's, epilepsy, ALS and multiple sclerosis. Co-authors also include Chad Morgan, MD, Kenneth Wagner, PhD, Elizabeth Dulaney, Janice Carrozzella, RN, Daniel Kanter, MD, and Mario Zuccarello, MD.


Story Source:

The above story is based on materials provided by University Of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University Of Cincinnati. "Researchers Discover Molecule That Causes Secondary Stroke." ScienceDaily. ScienceDaily, 1 June 2005. <www.sciencedaily.com/releases/2005/05/050528125318.htm>.
University Of Cincinnati. (2005, June 1). Researchers Discover Molecule That Causes Secondary Stroke. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2005/05/050528125318.htm
University Of Cincinnati. "Researchers Discover Molecule That Causes Secondary Stroke." ScienceDaily. www.sciencedaily.com/releases/2005/05/050528125318.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins