Featured Research

from universities, journals, and other organizations

MRI Can Help Predict Breast Cancer Recurrence

Date:
June 20, 2005
Source:
American Roentgen Ray Society
Summary:
MRI measurement of breast tumor volume -- before, during and after chemotherapy -- can help predict whether a patient's cancer will return, a new study shows.

MRI measurement of breast tumor volume—before, during and after chemotherapy—can help predict whether a patient’s cancer will return, a new study shows.

The study, performed at the University of California-San Francisco, of 58 breast cancer patients found that the best way to predict a patient's recurrence-free survival is to review the initial MR examination (before the patient has chemotherapy) and the final MR examination (after chemotherapy has been completed). “Initial tumor volume was a strong predictor of recurrence free survival. Of the women who had tumor volumes of 33 cm3 or less on the initial MR exam, 93% remained disease free after two years, compared with 70% of the women with larger tumors. This speaks strongly for the value of early detection,” said Savannah C. Partridge, PhD, now an assistant professor of radiology at the University of Washington, Seattle.

“The change in tumor volume with treatment was also a valuable predictor,” said Dr. Partridge. “We found that the group of patients who had a 50% or greater reduction in MRI tumor volume when comparing the first MR examination to the last had a better recurrence-free survival rate (87% remained disease-free after two years) than those with less tumor shrinkage during chemotherapy treatment (64% were disease-free after two years), irrespective of their initial tumor volumes,” she added.

One patient with a large focal mass showed a substantial decrease in tumor volume on MRI during treatment, and continues to be disease-free 40 months after surgery. In contrast, a second patient, with a more diffuse mass, showed an increase in tumor volume on MRI during treatment that was not detected by clinical examination. Her disease returned eight months after surgery, said Dr. Partridge.

Most often, MRI is used to measure the tumor’s diameter, said Dr. Partridge. “This study shows that while measuring tumor diameter is useful for staging, volume is preferable for monitoring treatment because 3D volume measurements can more accurately capture the extent of irregularly shaped tumors, multifocality and diffuse shrinkage of lesions during treatment,” she said. “It is important that an accurate and validated tool be used for calculation of 3D tumor volume from MRI images,” she noted.

Physicians now typically evaluate treatment response by clinical exam and pathology. “But unlike pathology, early changes in tumor volume can potentially be assessed by MRI at a time when chemotherapy regimens can still be modified. Our study showed that MRI measurements of breast tumor volume can help predict recurrence-free survival. We are encouraged by these results and anticipate that monitoring tumor response by MRI will help us to better tailor treatment strategies for individual patients. A larger multi-center study is currently underway to see if MRI can determine if chemotherapy is working early enough for treatment to be changed,” she said.

The study appears in the June 2005 issue of the American Journal of Roentgenology.


Story Source:

The above story is based on materials provided by American Roentgen Ray Society. Note: Materials may be edited for content and length.


Cite This Page:

American Roentgen Ray Society. "MRI Can Help Predict Breast Cancer Recurrence." ScienceDaily. ScienceDaily, 20 June 2005. <www.sciencedaily.com/releases/2005/06/050620004318.htm>.
American Roentgen Ray Society. (2005, June 20). MRI Can Help Predict Breast Cancer Recurrence. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2005/06/050620004318.htm
American Roentgen Ray Society. "MRI Can Help Predict Breast Cancer Recurrence." ScienceDaily. www.sciencedaily.com/releases/2005/06/050620004318.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins