Featured Research

from universities, journals, and other organizations

Doctors Able To Predict Potential Ovarian Failure After Radiation

Date:
July 5, 2005
Source:
American Society for Therapeutic Radiology and Oncology
Summary:
Doctors in the United Kingdom have created a table to predict when a woman who has undergone radiation therapy as a part of cancer treatment regimen in her abdominal or pelvic area may become sterile, according to a new study published in the July 2005 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology.

Doctors in the United Kingdom have created a table to predict when a woman who has undergone radiation therapy as a part of cancer treatment regimen in her abdominal or pelvic area may become sterile, according to a new study published in the July 2005 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology.

Radiation therapy to the abdominal and pelvic regions in children and adolescents may potentially expose the ovaries to radiation and cause premature ovarian failure. Though their window of opportunity to become pregnant may be smaller, receiving radiation therapy does not preclude them from natural conception and a successful pregnancy. The researchers developed a formula that takes into account the age of the patient at the time of treatment, the number of premature eggs present at the time of treatment and the dose of radiation received to determine a window of fertility and at what age the woman may experience ovarian failure.

With the help of modern three-dimensional radiation therapy planning, clinicians are able to determine how much radiation the ovaries are exposed to and using the method they developed, the doctors would be able to determine a window of roughly 7.6 years for when a woman could expect to become infertile. The exact window of opportunity will vary from patient to patient.

"Our research has made it possible for doctors to predict when a young woman who has been successfully treated for cancer will develop ovarian failure," said Hamish Wallace, M.D., lead author of the study and Senior Lecturer at the University of Edinburgh and a children's cancer specialist at the Royal Hospital for Sick Children in Edinburgh, Scotland. "This will allow doctors to treat them with hormone replacement therapy and prevent osteoporosis and other disabling symptoms of the menopause. This knowledge will also guide patients and doctors to their future window of opportunity to have a baby. For those young women who are at risk of a very early menopause, it is now possible to counsel them of the options currently available to preserve their fertility before their treatment starts."

"We acknowledge this is a predictive model based on pre-clinical work and does not take into account the current use of combined modality treatments in pediatric and adolescent cancer survivors," said Frank Saran, M.D., co-author of the study and Consultant Clinical Oncologist and Honorary Senior Lecturer at Royal Marsden NHS Trust Foundation in Sutton, United Kingdom. "We hope this enables doctors to confidently counsel women on their reproductive potential following the successful treatment of their cancer."

"This information can be used either to vary the treatment -- so that less radiation is received by the ovary -- or possibly commence freezing of ovarian tissue, which is a new technique that potentially enables fertility after serious damage to the ovaries," said Tom W. Kelsey, B.Sc., M.Sc., Ph.D., co-author of the study and a computer scientist at University of St. Andrews in Scotland. "Our results are exciting and useful, and further data is needed to improve the accuracy of our methods."

###

For more information on radiation therapy for gynecologic cancer, please visit www.astro.org/patient/treatment_information/ for a free brochure.

ASTRO is the largest radiation oncology society in the world, with more than 8,000 members who specialize in treating patients with radiation therapies. As a leading organization in radiation oncology, biology and physics, the Society is dedicated to the advancement of the practice of radiation oncology by promoting excellence in patient care, providing opportunities for educational and professional development, promoting research and disseminating research results and representing radiation oncology in a rapidly evolving socioeconomic healthcare environment.


Story Source:

The above story is based on materials provided by American Society for Therapeutic Radiology and Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Therapeutic Radiology and Oncology. "Doctors Able To Predict Potential Ovarian Failure After Radiation." ScienceDaily. ScienceDaily, 5 July 2005. <www.sciencedaily.com/releases/2005/07/050705010828.htm>.
American Society for Therapeutic Radiology and Oncology. (2005, July 5). Doctors Able To Predict Potential Ovarian Failure After Radiation. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2005/07/050705010828.htm
American Society for Therapeutic Radiology and Oncology. "Doctors Able To Predict Potential Ovarian Failure After Radiation." ScienceDaily. www.sciencedaily.com/releases/2005/07/050705010828.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins