Featured Research

from universities, journals, and other organizations

Aspirin Treatment Failure Warning

Date:
August 14, 2005
Source:
Research Australia
Summary:
Treatment failures occur with any drug and aspirin is no exception. Evidence is growing that some people will not respond to the anti-coagulant action of aspirin and the drug will not protect against cardiovascular events despite its regular intake.

Treatment failures occur with any drug and aspirin is no exception.Evidence is growing that some people will not respond to theanti-coagulant action of aspirin and the drug will not protect againstcardiovascular events despite its regular intake.

Professor Andrew Szczeklik from Poland and Professor Graeme Hankeyfrom Western Australia will present the latest findings on aspirinresistance at the XXth Congress of the International Society ofThrombosis and Haemostasis today.

"There are at least two possible explanations for theaspirin-resistance phenomenon," said Professor Szczeklik. "One is highlevels of blood cholesterol, which can in itself promote coagulationevents in the blood stream. In patients with high cholesterol levels,aspirin in in normal doses has hardly any anti-clotting effects,whereas treatment with a statin (inhibitor of cholesterol)significantly reduces blood clotting. In patients with coronary heartdisease, aspirin exerts it anti-coagulant effects only when bloodcholesterol is in the 'normal' range."

Szczeklik went onto say, "A patients genetic make-up may altertheir response to aspirin resistance.. For example, in coronary heartdisease patients carrying one particular gene are resistant to theanti-coagulant action of aspirin and are at increased risk of an acutecoronary event."

Perth researcher, Professor Graeme Hankey, has shown thatpatients who show evidence of aspirin resistance do respond well toanother drug called Clopidogrel.

"Clopidogrel had anti-clotting and anti-inflammatory effectsin patients with diseased arteries. These effects were greatest in theaspirin-resistant patients," said Hankey.

"The use of aspirin has risen dramatically in Australia in thelate 1990's. This is why it is vital that aspirin resistance isconsidered when implementing anti-clotting therapy. Present dataindicate that this particularly applies to survivors of a heart attackor unstable angina, patients receiving bypass surgery as well as peoplewith high cholesterol," reported Hankey.


Story Source:

The above story is based on materials provided by Research Australia. Note: Materials may be edited for content and length.


Cite This Page:

Research Australia. "Aspirin Treatment Failure Warning." ScienceDaily. ScienceDaily, 14 August 2005. <www.sciencedaily.com/releases/2005/08/050811104703.htm>.
Research Australia. (2005, August 14). Aspirin Treatment Failure Warning. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2005/08/050811104703.htm
Research Australia. "Aspirin Treatment Failure Warning." ScienceDaily. www.sciencedaily.com/releases/2005/08/050811104703.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins