Featured Research

from universities, journals, and other organizations

Mutation May Raise Prostate-cancer Risk In African Americans

Date:
September 21, 2005
Source:
Ohio State University
Summary:
Researchers have identified a gene mutation that may increase the risk of prostate cancer up to three times in African-American men with a family history of the disease. The study, by scientists at 13 research centers, found that mutations in a gene known as EphB2 occurred in 15 percent of African-American men with a strong family history of prostate cancer.

Related Articles


Thestudy, by scientists at 13 research centers, found that mutations in agene known as EphB2 occurred in 15 percent of African-American men witha strong family history of prostate cancer. The mutation was found inonly 5 percent of African-American men with no family or personalhistory of the disease and in less than 2 percent of European-Americanmen with no history of the disease.

Prostate cancer rates areextremely high in African-American men. They develop the disease 60percent more often than do European Americans, and they are almost twoand half times more likely to die of the disease.

Until now, nogene mutations have been identified that contribute to hereditaryprostate cancer and prostate-cancer susceptibility specifically inAfrican-American men.

The findings are published online in the Sept. 9, 2005, issue of the Journal of Medical Genetics.

“Thisis the first gene mutation to be associated with familial prostatecancer in African-American men,” says first author Rick A. Kittles,associate professor of molecular virology, immunology and medicalgenetics and a researcher with the Human Cancer Genetics program at TheOhio State University Comprehensive Cancer Center – Arthur G. JamesCancer Hospital and Richard J. Solove Research Institute.

“Next,we must learn more about how this mutation contributes to cancer, andwe must screen for the mutation in a much larger group ofAfrican-American men with prostate cancer to verify its associationwith the disease.”

Then, says Kittles, a specialist inprostate-cancer genetics in African Americans, “perhaps we can beginusing this mutation to help estimate prostate-cancer risk inAfrican-American men.”

The findings are the first to come out ofthe African-American Hereditary Prostate Cancer (AAHPC) study network,a group of 112 African-American families nationally who havevolunteered to help in research to identify genetic risk factors forprostate cancer. Families in the network have had four or more cases ofprostate cancer in the family.

“This as an exciting extension toour original findings implicating EphB2 as a prostate-cancertumor-suppressor gene,” says principal investigator John D. Carpten, ofthe Translational Genomics Research Institute.

“These data nowsuggest that mutations in this gene might predispose African-Americanmen to prostate cancer in a significant way.”

Other evidencesuggesting that EphB2 could be a prostate-cancer susceptibility geneinclude its location on chromosome 1. The exact function of the gene isunknown.

For this study, the researchers isolated the EphB2 genefrom white blood cells taken from 72 African-American men in the AAHPCwith hereditary prostate cancer and examined them for mutations.

Aftersequencing the gene from each volunteer, the investigators found that11 of the 72 men (15.3 percent) had a mutation designated K1019X. Thesame mutation was found in only 5.2 percent in a control group of 329healthy African-American men and in only 1.7 percent of 231European-American control samples.

The findings indicate that theK1019X mutation is found mainly in African-American men, that it isparticularly prevalent in African-American men with a family history ofprostate cancer, and that it increases the risk of prostate cancer inthese men almost three-fold.

“Given its high frequency inhereditary cases, we believe that this mutation is probably associatedwith hereditary prostate cancer in African-American men,” Kittles says.

Fundingfrom the National Institutes of Health (NIH) Center for Minority Healthand Health Disparities, the National Cancer Institute, the Departmentof Defense, the U.S. Public Health Service and the Commonwealth ofPennsylvania supported this research.

The other centersparticipating in the study were the Fox Chase Cancer Center;Translational Genomics Research Institute; the National Genome Centerat Howard University; The University of Texas MD Anderson CancerCenter; University of California Davis Cancer Center; Midtown UrologySurgical Center, Atlanta, Georgia; Columbia University Medical Center;the University of Illinois at Chicago; Medical College of GeorgiaSchool of Nursing; National Human Genome Research Institute; the NIHCenter for Inherited Disease Research; and the Karmanos CancerInstitute.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Mutation May Raise Prostate-cancer Risk In African Americans." ScienceDaily. ScienceDaily, 21 September 2005. <www.sciencedaily.com/releases/2005/09/050921075105.htm>.
Ohio State University. (2005, September 21). Mutation May Raise Prostate-cancer Risk In African Americans. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2005/09/050921075105.htm
Ohio State University. "Mutation May Raise Prostate-cancer Risk In African Americans." ScienceDaily. www.sciencedaily.com/releases/2005/09/050921075105.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins