Featured Research

from universities, journals, and other organizations

Mechanism Regulating Tooth Shape Formulation Found

Date:
September 23, 2005
Source:
University of Helsinki
Summary:
One of the remaining challenges for evolutionary developmental studies of mammals, whose evolution is best known from their teeth, is how their tooth shape is altered during development. Researchers of the University of Helsinki together with their Japanese colleagues from the University of Kioto now propose a 'balance of induction' mechanism directing the placement of tooth shape features called cusps.

One of the remaining challenges for evolutionary developmental studiesof mammals, whose evolution is best known from their teeth, is howtheir tooth shape is altered during development. Researchers of theUniversity of Helsinki together with their Japanese colleagues from theUniversity of Kioto now propose a 'balance of induction' mechanismdirecting the placement of tooth shape features called cusps. Positionand shape of cusps determine whether a tooth shape belongs to human ormouse, for example. Whereas developmental initiation of cusp formationis known to involve several developmental genes at the places of futurecusps, it has remained unknown how cusps form at the right places.

Computer simulations on tooth development have suggested that thereshould be a gene inhibiting induction of cusps. The research team hasnow identified this inhibitor to be a recently identified gene calledectodin. It turned out that ectodin is the first gene that is expressedas a mirror image of the future cusps.

The team generated a mouse that has no functional ectodin. Whereas themice appear fairly normal, the areas forming cusps were much broaderresulting in cheek teeth whose shape resembles more rhinoceros teeththan mouse teeth. Furthermore, these mice have extra teeth andsometimes adjacent teeth are fused. These results indicate that thereis a delicate balance of induction and inhibition in determining toothcusps and that ectodin is a key gene in this developmental control.

The team confirmed the importasnce of ectodin to development of teethby culturing teeth that produce ectodin and teeth that lack ectodinwith excess amounts of cusp inducing protein (bone morphogeneticprotein or BMP). Whereas teeth producing ectodin develop quite normallywith excess BMP, teeth without ectodin had a markedly acceleratedinduction of cusps. Indeed the researchers were able to induce cuspsand mineralization of teeth much faster than happens in normal mouseteeth, suggesting that tinkering with the balance of cusp induction mayhold potential for future tissue engineering of hard tissues.

###

Article: Regulation of mammalian tooth cusp patterning by ectodin.
Yoshiaki Kassai, Pauliina Munne, Yuhei Hotta, Enni Penttilδ, KathrynKavanagh, Norihiko Ohbayashi, Shinji Takada, Irma Thesleff, JukkaJernvall, Nobuyuki Itoh.
Science, Sept. 23, 2005


Story Source:

The above story is based on materials provided by University of Helsinki. Note: Materials may be edited for content and length.


Cite This Page:

University of Helsinki. "Mechanism Regulating Tooth Shape Formulation Found." ScienceDaily. ScienceDaily, 23 September 2005. <www.sciencedaily.com/releases/2005/09/050923153933.htm>.
University of Helsinki. (2005, September 23). Mechanism Regulating Tooth Shape Formulation Found. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2005/09/050923153933.htm
University of Helsinki. "Mechanism Regulating Tooth Shape Formulation Found." ScienceDaily. www.sciencedaily.com/releases/2005/09/050923153933.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) — State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) — The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) — CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) — A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins