Featured Research

from universities, journals, and other organizations

Intake Of Dietary Copper Helps Alzheimer's Patients

Date:
October 4, 2005
Source:
Case Western Reserve University
Summary:
As one of the services for patients with Alzheimer's disease, the Department of Psychiatry at the Saarland University Medical Center offers participation in a clinical phase II trial. This clinical trial aims to elucidate a potential beneficial effect of copper orotate (an organic copper salt), which is given together with a standard cholinesterase inhibitor. A diagnosis of mild to moderate dementia of the Alzheimer type is a prerequisite.

Treatmentstarts after all prerequisites to participate have been met. Half ofthe patients receive 8 mg copper orotate per day, the other half aplacebo. Both patients and psychiatrists are blinded. During the12-month long double-blind phase, there will be extensive laboratory,clinical and neuropsychological tests. After the double-blind phase, weoffer an open-label phase for all patients. At present, 15 patientshave finished the double-blind phase. The copper medication is welltolerated.

Alzheimer is characterized by the presence of amyloidplaques, which are composed primarily of Aß peptide. Aß is producedwithin neurons and is liberated from the larger amyloid ß proteinprecursor (AßPP). Lower levels of copper have been reported in thebrain of AßPP transgenic mice and post-mortem in AD patients. Thisconcept has been found to be true also in vitro by Professor Dr. GerdMulthaup (FU Berlin) in 1999. Two recent papers, which have beenpublished in PNAS in 2003 have proven a beneficial effect of elevatedcopper in transgenic AßPP mice. In the present study, the teams led byBayer and Multhaup have found that low copper level in blood correlateswith advanced memory deficits, as tested by the well establishedADAS-cog neuropsychological test battery. Patients with higher bloodcopper levels make fewer mistakes in this memory test. This resultsupports the notion of a mild copper deficiency in AD patients. Anincreased uptake of dietary copper may therefore be therapeuticallyrelevant.

###

The study has been published in the September2005 issue of the Journal of Alzheimer's Disease, Volume 8, Issue 1published by IOS Press: "Cognitive decline correlates with low plasmaconcentrations of copper in patients with mild to moderate Alzheimer'sdisease" (JAD, Vol. 8, Issue 1).



Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "Intake Of Dietary Copper Helps Alzheimer's Patients." ScienceDaily. ScienceDaily, 4 October 2005. <www.sciencedaily.com/releases/2005/10/051004084327.htm>.
Case Western Reserve University. (2005, October 4). Intake Of Dietary Copper Helps Alzheimer's Patients. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2005/10/051004084327.htm
Case Western Reserve University. "Intake Of Dietary Copper Helps Alzheimer's Patients." ScienceDaily. www.sciencedaily.com/releases/2005/10/051004084327.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) — Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins