Featured Research

from universities, journals, and other organizations

Study Identifies Risk Factors For Multiple Melanoma Skin Cancer

Date:
October 5, 2005
Source:
JAMA and Archives Journals
Summary:
Patients with a family history of multiple melanoma skin cancer are at increased risk of multiple primary melanomas, according to a study in the October 5 issue of JAMA.

Patients with a family history of multiple melanoma skin cancer are atincreased risk of multiple primary melanomas, according to a study inthe October 5 issue of JAMA.

Related Articles


In 2005, there will be an estimated 62,000 new cases of invasivemelanoma and an estimated 7,600 deaths due to melanoma in the UnitedStates, according to background information in the article. Melanoma isthe fifth leading cancer in men and the sixth leading cancer in womenin the United States. The incidence of melanoma continues to rise atabout 3 percent per year in the United States, with an estimatedlifetime risk for an individual of 1.4 percent. This increasingincidence puts a larger portion of the population at risk not only forone primary melanoma but also for subsequent primary melanomas.

Cristina R. Ferrone, M.D., and colleagues from Memorial Sloan-KetteringCancer Center, New York, conducted a study to identify the incidenceand characteristics of patients at risk of developing multiple primarymelanomas (MPM). The study included 4,484 patients diagnosed with afirst primary melanoma between January 1, 1996, and December 31, 2002.

The researchers found that 385 patients (8.6 percent) had 2 or moreprimary melanomas, with an average of 2.3 melanomas per MPM patient.Seventy-eight percent had 2 primary melanomas. For 74 percent ofpatients, the initial melanoma was the thickest tumor. Fifty-ninepercent presented with their second primary tumor within 1 year.Twenty-one percent of MPM patients had a positive family history ofmelanoma compared with only 12 percent of patients with a singleprimary melanoma (SPM). Thirty-eight percent of MPM patients haddysplastic nevi (DN; atypical moles) compared with 18 percent of SPMpatients.

The estimated cumulative 5-year risk of a second primary tumor for theentire cohort was 11.4 percent, with almost half of that risk occurringwithin the first year. For patients with a positive family history ordysplastic nevi, the estimated 5-year risk of MPM was significantlyhigher at 19.1 percent and 23.7 percent, respectively. The moststriking increase in incidence for the MPM population was seen fordevelopment of a third primary melanoma from the time of second primarymelanoma, which was 15.6 percent at 1 year and 30.9 percent at 5 years.

"Patients with a positive family history or a history of DN are atsignificantly greater risk of developing MPM and should be enrolled inmore intensive dermatologic surveillance programs. This high-risksubset of patients should also be further characterized genetically tofurther elucidate the biology and etiology of melanoma," the authorsconclude.



Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Study Identifies Risk Factors For Multiple Melanoma Skin Cancer." ScienceDaily. ScienceDaily, 5 October 2005. <www.sciencedaily.com/releases/2005/10/051005075345.htm>.
JAMA and Archives Journals. (2005, October 5). Study Identifies Risk Factors For Multiple Melanoma Skin Cancer. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2005/10/051005075345.htm
JAMA and Archives Journals. "Study Identifies Risk Factors For Multiple Melanoma Skin Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/10/051005075345.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins