Featured Research

from universities, journals, and other organizations

Candidate Hookworm Vaccine Shows Benefits In Animal Study

Date:
October 8, 2005
Source:
Public Library of Science
Summary:
In a paper in the open access journal PLoS Medicine, vaccination of dogs with a recombinant protease produced by hookworms can reduce blood loss when these dogs are infected with the hookworm Ancylostoma caninum.

Hookworms secrete proteins that are being used as vaccines in animal models.
Credit: Photo : Loukas et al.

Hookwormsare intestinal parasites of mammals, including humans, dogs, and cats;in humans these infections are a leading cause of intestinal blood lossand iron-deficiency anemia. Hookworm infections occur mostly intropical and subtropical climates and are estimated to infect about 1billion people worldwide-- about one-fifth of the world's population.People who have direct contact with soil that contains human feces inareas where hookworm is common are at high risk of infection; becausechildren play in dirt, they are at the highest risk.

Theseresults set the stage for the next stage of vaccine development inhumans. Loukas and colleagues suggest that the ideal hookworm vaccinewould be a mixture of two recombinant proteins, targeting both theinfective larva and the blood-feeding adult stage (as targeted here) ofthe parasite. Such a vaccine would limit the amount of blood losscaused by feeding worms and maintain normal levels of hemoglobin.

###

Citation:Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, et al. (2005)Vaccination with recombinant aspartic hemoglobinase reduces parasiteload and blood loss after hookworm infection. PLoS Med 2(10): e295.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Candidate Hookworm Vaccine Shows Benefits In Animal Study." ScienceDaily. ScienceDaily, 8 October 2005. <www.sciencedaily.com/releases/2005/10/051007101024.htm>.
Public Library of Science. (2005, October 8). Candidate Hookworm Vaccine Shows Benefits In Animal Study. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2005/10/051007101024.htm
Public Library of Science. "Candidate Hookworm Vaccine Shows Benefits In Animal Study." ScienceDaily. www.sciencedaily.com/releases/2005/10/051007101024.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins