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Candidate Hookworm Vaccine Shows Benefits In Animal Study

Date:
October 8, 2005
Source:
Public Library of Science
Summary:
In a paper in the open access journal PLoS Medicine, vaccination of dogs with a recombinant protease produced by hookworms can reduce blood loss when these dogs are infected with the hookworm Ancylostoma caninum.
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FULL STORY

Hookworms secrete proteins that are being used as vaccines in animal models.
Credit: Photo : Loukas et al.

Hookwormsare intestinal parasites of mammals, including humans, dogs, and cats;in humans these infections are a leading cause of intestinal blood lossand iron-deficiency anemia. Hookworm infections occur mostly intropical and subtropical climates and are estimated to infect about 1billion people worldwide-- about one-fifth of the world's population.People who have direct contact with soil that contains human feces inareas where hookworm is common are at high risk of infection; becausechildren play in dirt, they are at the highest risk.

Theseresults set the stage for the next stage of vaccine development inhumans. Loukas and colleagues suggest that the ideal hookworm vaccinewould be a mixture of two recombinant proteins, targeting both theinfective larva and the blood-feeding adult stage (as targeted here) ofthe parasite. Such a vaccine would limit the amount of blood losscaused by feeding worms and maintain normal levels of hemoglobin.

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Citation:Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, et al. (2005)Vaccination with recombinant aspartic hemoglobinase reduces parasiteload and blood loss after hookworm infection. PLoS Med 2(10): e295.


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Public Library of Science. "Candidate Hookworm Vaccine Shows Benefits In Animal Study." ScienceDaily. ScienceDaily, 8 October 2005. <www.sciencedaily.com/releases/2005/10/051007101024.htm>.
Public Library of Science. (2005, October 8). Candidate Hookworm Vaccine Shows Benefits In Animal Study. ScienceDaily. Retrieved April 26, 2015 from www.sciencedaily.com/releases/2005/10/051007101024.htm
Public Library of Science. "Candidate Hookworm Vaccine Shows Benefits In Animal Study." ScienceDaily. www.sciencedaily.com/releases/2005/10/051007101024.htm (accessed April 26, 2015).

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