Featured Research

from universities, journals, and other organizations

Candidate Hookworm Vaccine Shows Benefits In Animal Study

Date:
October 8, 2005
Source:
Public Library of Science
Summary:
In a paper in the open access journal PLoS Medicine, vaccination of dogs with a recombinant protease produced by hookworms can reduce blood loss when these dogs are infected with the hookworm Ancylostoma caninum.

Hookworms secrete proteins that are being used as vaccines in animal models.
Credit: Photo : Loukas et al.

Hookwormsare intestinal parasites of mammals, including humans, dogs, and cats;in humans these infections are a leading cause of intestinal blood lossand iron-deficiency anemia. Hookworm infections occur mostly intropical and subtropical climates and are estimated to infect about 1billion people worldwide-- about one-fifth of the world's population.People who have direct contact with soil that contains human feces inareas where hookworm is common are at high risk of infection; becausechildren play in dirt, they are at the highest risk.

Theseresults set the stage for the next stage of vaccine development inhumans. Loukas and colleagues suggest that the ideal hookworm vaccinewould be a mixture of two recombinant proteins, targeting both theinfective larva and the blood-feeding adult stage (as targeted here) ofthe parasite. Such a vaccine would limit the amount of blood losscaused by feeding worms and maintain normal levels of hemoglobin.

###

Citation:Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, et al. (2005)Vaccination with recombinant aspartic hemoglobinase reduces parasiteload and blood loss after hookworm infection. PLoS Med 2(10): e295.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Candidate Hookworm Vaccine Shows Benefits In Animal Study." ScienceDaily. ScienceDaily, 8 October 2005. <www.sciencedaily.com/releases/2005/10/051007101024.htm>.
Public Library of Science. (2005, October 8). Candidate Hookworm Vaccine Shows Benefits In Animal Study. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2005/10/051007101024.htm
Public Library of Science. "Candidate Hookworm Vaccine Shows Benefits In Animal Study." ScienceDaily. www.sciencedaily.com/releases/2005/10/051007101024.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins