Featured Research

from universities, journals, and other organizations

Estrogen And Exercise Promote Leanness In Similar Ways

Date:
November 5, 2005
Source:
USDA/Agricultural Research Service
Summary:
A common hormone has been found to help the body use fat and glucose as energy in the same way that exercise does. Agricultural Research Service-funded scientists report the findings -- based on animal studies -- in the Journal of Biological Chemistry.

A common hormone has been found to help the body use fat and glucose as energy in the same way that exercise does. Agricultural Research Service-funded scientists report the findings -- based on animal studies -- in the Journal of Biological Chemistry.

The study, led by physician Andrew Greenberg and colleagues, actually reveals a number of novel mechanisms by which estrogen promotes a reduction in fat cell size and fat tissue mass. Greenberg is director of the Obesity and Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston, Mass.

Estrogen is an important hormone in both women and men. It activates pathways that regulate metabolism and also directly regulates the expression of certain genes. The results shown were based on providing half of a group of laboratory mice that had no ovaries with a placebo pellet and the other half an estrogen pellet for 40 days. The mice were fed equal amounts of chow.

In the mice, estrogen replacement was found to reduce lipids, or fats, by promoting the use of fat as fuel. The three mechanisms for the observed action include: inhibiting fat storage in liver, muscle and fat tissue; activating the pathways that promote burning the fat in muscles; and breaking down stored fats used for energy reserves in fat cells.

When estrogen was present in muscle, liver and fat cells, the expression of genes that control manufacturing and storing fat was reduced, and the expression of genes that promote burning fat in muscle cells was increased.

Scientists long have known that fading estrogen levels lead postmenopausal women to accumulate more fat and sometimes develop insulin resistance or diabetes. The study demonstrates that estrogen may reduce body fat in animals and may explain some of the reasons behind the association of menopause with increased risk of insulin resistance and diabetes, according to Greenberg.

ARS is the U.S. Department of Agriculture’s chief in-house scientific research agency.


Story Source:

The above story is based on materials provided by USDA/Agricultural Research Service. Note: Materials may be edited for content and length.


Cite This Page:

USDA/Agricultural Research Service. "Estrogen And Exercise Promote Leanness In Similar Ways." ScienceDaily. ScienceDaily, 5 November 2005. <www.sciencedaily.com/releases/2005/11/051105090331.htm>.
USDA/Agricultural Research Service. (2005, November 5). Estrogen And Exercise Promote Leanness In Similar Ways. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/11/051105090331.htm
USDA/Agricultural Research Service. "Estrogen And Exercise Promote Leanness In Similar Ways." ScienceDaily. www.sciencedaily.com/releases/2005/11/051105090331.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins