Featured Research

from universities, journals, and other organizations

ADHD Medication Might Also Treat Hyperactivity Symptoms In Autism

Date:
November 22, 2005
Source:
Yale University
Summary:
Methylphenidate, a medication used to treat attention-deficit hyperactivity disorder (ADHD), may be effective in treating hyperactivity symptoms in children with autism and related pervasive developmental disorders, researchers report in the November Archives of General Psychiatry.

Methylphenidate, a medication used to treat attention-deficit hyperactivity disorder (ADHD), may be effective in treating hyperactivity symptoms in children with autism and related pervasive developmental disorders, researchers report in the November Archives of General Psychiatry.

The study was conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network, a National Institute of Mental Health funded multi-site consortium dedicated to the development and testing of treatments for children with pervasive developmental disorders such as autism. The Yale team is directed by Lawrence Scahill, associate professor of nursing and child psychiatry at Yale.

"This study shows that methylphenidate is an effective medication for children with pervasive developmental disorder (PDD) accompanied by increased hyperactivity," said Scahill. "However, the percentage of children showing a positive response and the magnitude of benefit is lower than what we have come to expect in ADHD uncomplicated by PDD."

"Although the adverse effects that we observed in this study are similar to what we see in typically developing children with ADHD, these adverse effects occurred at a much higher frequency in our study subjects, " Scahill added.

RUPP investigators conducted a randomized, placebo-controlled trial to determine whether methylphenidate would be effective in reducing hyperactivity in children with PDD. The trial included a one-week test phase to ensure that subjects could tolerate three different dose levels of the medication, followed by a four-week (crossover) phase in which children were given one of three doses of methylphenidate or placebo to assess effectiveness. Parents, teachers and investigators, who rated the child's behavior, were blind to the child's drug dose. Children showing a positive response to any dose during the crossover phase were treated for an additional eight-week period to ensure the gains were stable.

The study evaluated 72 children between the ages of five and 14. Of the 58 participants who completed the crossover phase, 35 responded best to an active dose of methylphenidate and the drug was consistently more effective than placebo on measures of inattention, hyperactivity and impulsivity rated by parents and teachers.

###

The National Institute of Mental Health funded the study.

Other Yale authors on the study were Andres Martin, M.D., Kathleen Koenig, Deirdre Carroll, Christopher Young, M.D. and Allison Lancor. Authors from the RUPP Autism Network were from Indiana University, Johns Hopkins University, The Ohio State University, UCLA, the General Clinical Research Centers, National Center for Research Resources and the Korczak Foundation.

Citation: Archives of General Psychiatry, 62: 1266-74 (November 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "ADHD Medication Might Also Treat Hyperactivity Symptoms In Autism." ScienceDaily. ScienceDaily, 22 November 2005. <www.sciencedaily.com/releases/2005/11/051121165527.htm>.
Yale University. (2005, November 22). ADHD Medication Might Also Treat Hyperactivity Symptoms In Autism. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2005/11/051121165527.htm
Yale University. "ADHD Medication Might Also Treat Hyperactivity Symptoms In Autism." ScienceDaily. www.sciencedaily.com/releases/2005/11/051121165527.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins