Featured Research

from universities, journals, and other organizations

Cholesterol-lowering Drugs Not Associated With Reduced Colorectal Cancer Risk

Date:
January 5, 2006
Source:
Journal of the National Cancer Institute
Summary:
Use of cholesterol reducing drugs is not associated with a reduced risk of colorectal cancer, according to a study in the January 4 issue of the Journal of the National Cancer Institute.

Use of cholesterol reducing drugs is not associated with a reduced risk of colorectal cancer, according to a study in the January 4 issue of the Journal of the National Cancer Institute .

Related Articles


Previous studies have investigated the association between statins, the most commonly used type of cholesterol lowering drug, and colorectal cancer incidence, but these studies have produced mixed results. Several randomized trials, generally considered the most reliable type of study, found no clear association between statin use and colorectal cancer, but these trials were relatively small and did not examine long-term statin use. In contrast, a recent large study, the Molecular Epidemiology of Colorectal Cancer (MECC) study, which included almost 4000 people, showed that statin use for a period of more than 5 years was associated with a 47% reduction in the risk of colorectal cancer.

Eric J. Jacobs, Ph.D., of the American Cancer Society in Atlanta, and colleagues investigated the association between use of cholesterol-lowering drugs and colorectal cancer risk in the 132,136 men and women enrolled in the Cancer Prevention Study II Nutrition Cohort.

Researchers identified 815 cases of colorectal cancer in cohort participants during the period from 1997 to 2001. They found that use of cholesterol-lowering drugs, even use for 5 or more years, was not associated with colorectal cancer incidence.

This study measured use of cholesterol lowering drugs in general rather than use of statins in particular. However, the authors note that if statins strongly reduced the risk of colorectal cancer, use of any cholesterol-lowering drugs would likely have been associated with some reduction in risk because most users of cholesterol lowering drugs use statins.

"Our results do not support the hypothesis that statins, as a class of drugs, strongly reduce risk of colorectal cancer," they write.

In an accompanying editorial, John McLaughlin, Ph.D., of Cancer Care Ontario and the Prosserman Centre for Health Research in Ontario, calls the study a "prompt and timely contribution to the literature, because it capitalized on the existence of a large and well-characterized cohort." He writes that the study results suggest that a clinical trial that evaluates statins as a chemopreventive agent would be premature and that the results show that large cohort studies provide an excellent resource for hypothesis testing.

###

Citations:
Article: Jacobs EJ, Rodriguez C, Brady KA, Connell CJ, Thun MJ, Calle EE. Cholesterol-Lowering Drugs and Colorectal Cancer Incidence in a Large United States Cohort. J Natl Cancer Inst 2006;98:69-72.
Editorial: McLaughlin J. Stats on Statins: Anything but Static. J Natl Cancer Inst 2006;98:4-5.

Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Cholesterol-lowering Drugs Not Associated With Reduced Colorectal Cancer Risk." ScienceDaily. ScienceDaily, 5 January 2006. <www.sciencedaily.com/releases/2006/01/060105082112.htm>.
Journal of the National Cancer Institute. (2006, January 5). Cholesterol-lowering Drugs Not Associated With Reduced Colorectal Cancer Risk. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2006/01/060105082112.htm
Journal of the National Cancer Institute. "Cholesterol-lowering Drugs Not Associated With Reduced Colorectal Cancer Risk." ScienceDaily. www.sciencedaily.com/releases/2006/01/060105082112.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins