Featured Research

from universities, journals, and other organizations

History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease

Date:
February 8, 2006
Source:
JAMA and Archives Journals
Summary:
A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Related Articles


Previous studies have linked depression and Alzheimer's disease, according to background information in the article. People with a lifetime history of major depressive disorder (MDD) may be more likely to be diagnosed with AD. In addition, both AD and MDD are likely to affect the brain's memory-related temporal lobes. MDD is likely to caused atrophy of the hippocampus, the area where the largest amounts of plaques and tangles form in patients with AD, the authors write.

To assess how MDD might affect the development of AD, Michael A. Rapp, M.D., Ph.D., Mount Sinai School of Medicine, New York, and colleagues compared the brains of 44 AD patients with a history of depression to those of 51 without. The group included 32 men and 63 women with an average age at death of 81 years.

Patients with a history of depression had more tangles and plaques in the hippocampus than those without, the authors report. People who were depressed at the time they were diagnosed with AD had even more pronounced changes in their brains than those whose depression occurred earlier or later. Based on analyses of cognitive tests given during participants' lifetimes, patients with AD who had a history of depression also experienced a more rapid decline into dementia than those who did not have depression.

"These results have great clinical significance in that the identification of potential mechanisms that link geriatric MDD as a treatable risk factor to neuropathological changes in AD may lead to the development of differential intervention and prevention strategies for AD," the authors conclude. "Such specific interventions would be especially needed since geriatric patients with MDD with cognitive impairment may have less favorable treatment outcomes."

###

(Arch Gen Psychiatry. 2006;63:161-167. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: This study was supported in part by grants from the National Institute on Aging.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease." ScienceDaily. ScienceDaily, 8 February 2006. <www.sciencedaily.com/releases/2006/02/060206232204.htm>.
JAMA and Archives Journals. (2006, February 8). History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2006/02/060206232204.htm
JAMA and Archives Journals. "History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2006/02/060206232204.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins