Featured Research

from universities, journals, and other organizations

History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease

Date:
February 8, 2006
Source:
JAMA and Archives Journals
Summary:
A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Related Articles


Previous studies have linked depression and Alzheimer's disease, according to background information in the article. People with a lifetime history of major depressive disorder (MDD) may be more likely to be diagnosed with AD. In addition, both AD and MDD are likely to affect the brain's memory-related temporal lobes. MDD is likely to caused atrophy of the hippocampus, the area where the largest amounts of plaques and tangles form in patients with AD, the authors write.

To assess how MDD might affect the development of AD, Michael A. Rapp, M.D., Ph.D., Mount Sinai School of Medicine, New York, and colleagues compared the brains of 44 AD patients with a history of depression to those of 51 without. The group included 32 men and 63 women with an average age at death of 81 years.

Patients with a history of depression had more tangles and plaques in the hippocampus than those without, the authors report. People who were depressed at the time they were diagnosed with AD had even more pronounced changes in their brains than those whose depression occurred earlier or later. Based on analyses of cognitive tests given during participants' lifetimes, patients with AD who had a history of depression also experienced a more rapid decline into dementia than those who did not have depression.

"These results have great clinical significance in that the identification of potential mechanisms that link geriatric MDD as a treatable risk factor to neuropathological changes in AD may lead to the development of differential intervention and prevention strategies for AD," the authors conclude. "Such specific interventions would be especially needed since geriatric patients with MDD with cognitive impairment may have less favorable treatment outcomes."

###

(Arch Gen Psychiatry. 2006;63:161-167. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: This study was supported in part by grants from the National Institute on Aging.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease." ScienceDaily. ScienceDaily, 8 February 2006. <www.sciencedaily.com/releases/2006/02/060206232204.htm>.
JAMA and Archives Journals. (2006, February 8). History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2006/02/060206232204.htm
JAMA and Archives Journals. "History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2006/02/060206232204.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins