Featured Research

from universities, journals, and other organizations

History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease

Date:
February 8, 2006
Source:
JAMA and Archives Journals
Summary:
A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Previous studies have linked depression and Alzheimer's disease, according to background information in the article. People with a lifetime history of major depressive disorder (MDD) may be more likely to be diagnosed with AD. In addition, both AD and MDD are likely to affect the brain's memory-related temporal lobes. MDD is likely to caused atrophy of the hippocampus, the area where the largest amounts of plaques and tangles form in patients with AD, the authors write.

To assess how MDD might affect the development of AD, Michael A. Rapp, M.D., Ph.D., Mount Sinai School of Medicine, New York, and colleagues compared the brains of 44 AD patients with a history of depression to those of 51 without. The group included 32 men and 63 women with an average age at death of 81 years.

Patients with a history of depression had more tangles and plaques in the hippocampus than those without, the authors report. People who were depressed at the time they were diagnosed with AD had even more pronounced changes in their brains than those whose depression occurred earlier or later. Based on analyses of cognitive tests given during participants' lifetimes, patients with AD who had a history of depression also experienced a more rapid decline into dementia than those who did not have depression.

"These results have great clinical significance in that the identification of potential mechanisms that link geriatric MDD as a treatable risk factor to neuropathological changes in AD may lead to the development of differential intervention and prevention strategies for AD," the authors conclude. "Such specific interventions would be especially needed since geriatric patients with MDD with cognitive impairment may have less favorable treatment outcomes."

###

(Arch Gen Psychiatry. 2006;63:161-167. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: This study was supported in part by grants from the National Institute on Aging.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease." ScienceDaily. ScienceDaily, 8 February 2006. <www.sciencedaily.com/releases/2006/02/060206232204.htm>.
JAMA and Archives Journals. (2006, February 8). History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2006/02/060206232204.htm
JAMA and Archives Journals. "History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2006/02/060206232204.htm (accessed September 16, 2014).

Share This



More Mind & Brain News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com
'Fat Shaming' Might Actually Cause Weight Gain

'Fat Shaming' Might Actually Cause Weight Gain

Newsy (Sep. 11, 2014) A study for University College London suggests obese people who are discriminated against gain more weight than those who are not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins