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Can Dementia Spread From Mother To Offspring?

Date:
April 28, 2006
Source:
American Journal of Pathology
Summary:
Researchers have demonstrated spread of senile amyloidosis from affected mice to their nursing offspring. The paper by Korenaga et al., "Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis," appears in the March issue of the American Journal of Pathology and is highlighted on the cover of the Journal.

Researchers have demonstrated spread of senile amyloidosis from affected mice to their nursing offspring. The paper by Korenaga et al., "Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis," appears in the March issue of The American Journal of Pathology and is highlighted on the cover of the Journal.

Dementia can result from several disease mechanisms, including amyloidosis. Amyloidosis occurs when cellular proteins that normally float freely in the body form organized, nonfunctional aggregates, or fibrils, that cause cellular damage. This injury can lead to such disorders as Alzheimer's disease and Creutzfeld-Jakob disease, depending on the protein involved and where the fibrils accumulate.

Genetics are known to be involved in these disorders, but researchers have also shown that injecting fibrils into susceptible mice accelerates disease onset. That led researchers guided by Dr. Xiaoying Fu to ask whether pups born to affected mothers also display accelerated disease.

Using a mouse strain that carries a mutation for senile amyloidosis, Dr. Fu's group injected female mice with amyloid fibrils, to accelerate their disease, and then allowed the mice to mate and produce offspring. The mouse pups born to these mothers exhibited elevated levels of amyloid fibrils that increased with age. These fibrils were first seen in the intestines, spreading later to liver, spleen and other organs.

Interestingly, when mice born to injected mothers were nursed by control mothers (no fibrils injected), only one of nine pups had amyloid fibrils at 6 months. However, pups born to control mothers but nursed by injected mothers had amyloidosis at levels similar to that of pups born/nursed by injected mothers. The presence of fibrils in the milk of injected mothers was confirmed by protein assay and electron microscopy, and spread via the milk was demonstrated by injecting affected milk into naΓ―ve mice (fibrils were found at 3 months).

These authors use traditional "infectivity" concepts to show that ingestion of fibrils by nursing mouse pups, and not by events occurring in utero, transmits amyloid fibrils to their offspring, thus accelerating amyloidosis. Such events have not been observed in human amyloidosis but have been suggested in sheep scrapie, a prion disease related to Creutzfeld-Jakob disease.

Prion diseases, such as scrapie and bovine spongiform encephalopathy (mad cow), are known to be transmissible, with spread among susceptible hosts demonstrated in the laboratory and in the real world. Non-prion amyloidosis, however, has not been shown to spread in such a way until now.

Though provocative, the implications for such laboratory findings in human disease, such as Alzheimer's disease, are not clear. The study does, however, suggest interesting new areas for study of amyloidosis.

This work involved collaborators at the Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto; the Institute for Frontier Medical Science, Kyoto University, Kyoto; Fukui Medical University, Matsuoka; the Institute for Developmental Research, Aichi Human Service Center, Kasugai; and The Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan.

Korenaga T, Yan J, Sawashita J, Matsushita T, Naiki H, Hosokawa M, Mori M, Higuchi K, Fu X: Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. Am J Pathol 2006 168:898-906


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Cite This Page:

American Journal of Pathology. "Can Dementia Spread From Mother To Offspring?." ScienceDaily. ScienceDaily, 28 April 2006. <www.sciencedaily.com/releases/2006/04/060428141132.htm>.
American Journal of Pathology. (2006, April 28). Can Dementia Spread From Mother To Offspring?. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2006/04/060428141132.htm
American Journal of Pathology. "Can Dementia Spread From Mother To Offspring?." ScienceDaily. www.sciencedaily.com/releases/2006/04/060428141132.htm (accessed October 21, 2014).

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