Featured Research

from universities, journals, and other organizations

Unexpected Results Of Biopsies Performed On Women With Fertility Problems May Hold Hope For Those Trying To Conceive

Date:
May 17, 2006
Source:
Weizmann Institute of Science
Summary:
Louis Pasteur said that "chance favors the prepared mind." For Prof. Nava Dekel of the Weizmann Institute's Biological Regulation Department, some completely unexpected results of biopsies performed on women with fertility problems have led to a new path of scientific discovery that may hold hope for women trying to conceive.

Louis Pasteur said that "chance favors the prepared mind." For Prof. Nava Dekel of the Weizmann Institute's Biological Regulation Department, some completely unexpected results of biopsies performed on women with fertility problems have led to a new path of scientific discovery that may hold hope for women trying to conceive.

Related Articles


Dekel and a research team that includes Drs. Yael Kalma and Yulia Gnainsky, working in collaboration with Drs. Amichai Barash and Irit Granot of the Kaplan Medical Center, had been investigating a protein they suspected plays a role in the implantation of a fertilized egg in the uterus -- a crucial and sometimes failure-prone process. The team took biopsies at several stages in the menstrual cycles of 12 women with long histories of fertility problems and unsuccessful IVF treatments to see if levels of this protein changed over the course of the cycle.

Indeed, the team's research went according to plan and they found evidence pointing to the protein's role. The surprise came soon after: Of the 12 women participating in the study, 11 became pregnant during the next round of IVF. The idea of biopsy incisions, basically small wounds, leading to such a positive outcome was counterintuitive, and Dekel realized something interesting was happening. She and her team repeated the biopsies, this time on a group of 45 volunteers, and compared the results to a control group of 89 women who did not undergo biopsy. The results were clear: The procedure doubled a woman's chances of becoming pregnant.

On the basis of this and other evidence obtained from previous studies, the scientists suggest that some form of mild distress, such as a biopsy, may provoke a response that makes conditions in the uterus favorable for implantation. Dekel and her team are now looking for the exact mechanisms involved when an unreceptive uterus turns receptive following local injury. They are conducting both animal studies and human clinical trials to identify genes that may play a role in this process. In the future, this accidental finding may give birth to new treatments to improve the success rate of IVF or even tackle some types of fertility problems directly.

Prof. Nava Dekel's research is supported by the Y. Leon Benoziyo Institute for Molecular Medicine; the Willner Family Center for Vascular Biology; the Dwek Family Biomedical Research Fund; the Paul Godfrey Research Foundation in Children's Diseases; the Rachel and Shaul Peles Fund for Hormone Research; Mr. Max Candiotty, Los Angeles, CA; and Shimon Shestovich Ltd., Israel. Prof. Dekel is the incumbent of the Philip M. Klutznick Professorial Chair of Developmental Biology.


Story Source:

The above story is based on materials provided by Weizmann Institute of Science. Note: Materials may be edited for content and length.


Cite This Page:

Weizmann Institute of Science. "Unexpected Results Of Biopsies Performed On Women With Fertility Problems May Hold Hope For Those Trying To Conceive." ScienceDaily. ScienceDaily, 17 May 2006. <www.sciencedaily.com/releases/2006/05/060517000900.htm>.
Weizmann Institute of Science. (2006, May 17). Unexpected Results Of Biopsies Performed On Women With Fertility Problems May Hold Hope For Those Trying To Conceive. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2006/05/060517000900.htm
Weizmann Institute of Science. "Unexpected Results Of Biopsies Performed On Women With Fertility Problems May Hold Hope For Those Trying To Conceive." ScienceDaily. www.sciencedaily.com/releases/2006/05/060517000900.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins