Featured Research

from universities, journals, and other organizations

Microscopic Scaffolding Offers A 'Simple' Solution To Treating Skin Injuries

Date:
June 27, 2006
Source:
Engineering and Physical Sciences Research Council
Summary:
A revolutionary dissolvable scaffold for growing new areas of skin could provide a safer, more effective way of treating burns, diabetic ulcers and similar injuries.

Skin deep: microscope images of skin cells growing on scaffold fibres. In this fluorescent image, the fibres are red and the cell nuclei blue.
Credit: Image courtesy of Engineering and Physical Sciences Research Council

A revolutionary dissolvable scaffold for growing new areas of skin could provide a safer, more effective way of treating burns, diabetic ulcers and similar injuries.

Related Articles


This ultra-fine, 3-dimensional scaffold, which is made from specially developed polymers, looks similar to tissue paper but has fibres 100 times finer. Before it is placed over a wound, the patient’s skin cells (obtained via a biopsy*) are introduced and attach themselves to the scaffold, multiplying until they eventually grow over it. When placed over the wound, the scaffold dissolves harmlessly over 6 to 8 weeks, leaving the patient’s skin cells behind.

This new approach to skin reconstruction has been developed by a team of chemists, materials scientists and tissue engineers at the University of Sheffield, with funding from the Engineering and Physical Sciences Research Council. It is designed primarily for cases involving extensive burns where surgeons are unable to take enough skin grafts from elsewhere on the body to cover the damaged areas. Currently, bovine collagen** or skin from human donors is used in these cases, but these approaches have potential health and rejection risks.

"Simplicity is the key," says Professor Tony Ryan, who is leading the team. "Previous attempts to find better ways of encouraging skin cell growth have used chemical additives and other elaborate techniques to produce scaffolds, but their success has been limited. We’ve found that skin cells are actually very 'smart' – it’s in their DNA to sort themselves into the right arrangement. They just need a comparatively uncomplicated scaffold (and each other) to help them grow in a safe, natural way."

The polymers used in the scaffold are biodegradable materials already approved for medical applications. Because the team has recognised that skin cells are 'smart' and the scaffold can therefore be 'dumb' (i.e. not overly sophisticated), simple polymers can be used.

The process for making the scaffolds is based on the well-known technique of electrospinning***. However, the team has made a key advance by developing a new method of making, from the same biodegradable polymers, aligned-fibre 'mats' of potential use in promoting nerve or tendon growth. This method is currently being patented.

The next step in the research is to develop the skin reconstruction technology for clinical use, hopefully in the next few years. The technology also offers possibilities for testing the toxicity of cosmetic and similar products, using materials grown in the laboratory that closely resemble natural skin.

"Ultimately, we can envisage treatment of burns victims and the undertaking of reconstructive surgery using the scaffold and the patient's own skin to produce bespoke skin for that patient," says Professor Ryan. "As an accident-prone mountain biker, I find that prospect very attractive!"


Story Source:

The above story is based on materials provided by Engineering and Physical Sciences Research Council. Note: Materials may be edited for content and length.


Cite This Page:

Engineering and Physical Sciences Research Council. "Microscopic Scaffolding Offers A 'Simple' Solution To Treating Skin Injuries." ScienceDaily. ScienceDaily, 27 June 2006. <www.sciencedaily.com/releases/2006/06/060627234247.htm>.
Engineering and Physical Sciences Research Council. (2006, June 27). Microscopic Scaffolding Offers A 'Simple' Solution To Treating Skin Injuries. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2006/06/060627234247.htm
Engineering and Physical Sciences Research Council. "Microscopic Scaffolding Offers A 'Simple' Solution To Treating Skin Injuries." ScienceDaily. www.sciencedaily.com/releases/2006/06/060627234247.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins