Featured Research

from universities, journals, and other organizations

Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome

Date:
November 9, 2006
Source:
Fox Chase Cancer Center
Summary:
Researchers say an over-expression of COX-2 in men with prostate cancer is associated with an increase in PSA after radiation treatment and the spread of the cancer outside of the prostate. That is the result of the first study linking COX-2 with prostate cancer radiation treatment outcomes.

Researchers say an over-expression of COX-2 in men with prostate cancer is associated with an increase in PSA after radiation treatment and the spread of the cancer outside of the prostate. That is the result of the first study linking COX-2 (cyclooxygenase-2) with prostate cancer radiation treatment outcomes. The study, sponsored by the Radiation Therapy Oncology Group (RTOG 92-02), was presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia by Li-Yan Khor, M.D., a fellow in the Radiation Oncology Department at Fox Chase Cancer Center in Philadelphia.

"We found that an increased level of COX-2 prior to treatment was linked with biochemical failure and distant metastasis but was not predictive of overall survival," explained Khor.

For the study, Khor and colleagues analyzed 586 cases from RTOG 92-02 which had available tissue and suitable staining by immunohistochemistry. Median follow-up was 106.9 months. The intensity of COX-2 staining was quantified by automated image analysis provided by a commercial company.

The 5 year distant metastasis rate was 10.6 percent for a COX-2 intensity score less than 134, versus 14.1 percent for an intensity score greater than 134. A high intensity of COX-2 also predicted biochemical failure, the immediate PSA rise after treatment.

Khor added that data from animals have shown that inhibition of COX-2 suppresses angiogenesis (development of blood vessels) and the growth of prostate cancer, and is believed to make the cancer cells more sensitive to radiation therapy.

"This research suggest the need to know more about the levels of COX-2 in our patients," says Khor. "If men show increased levels of COX-2 perhaps radiation treatment will follow an attempt to inhibit COX-2 expression thereby making their cancer more responsive to radiation therapy."

Khor adds "Future studies in this area should include additional biopsy information to determine if COX-2 over-expression is associated with the inability to completely eliminate the cancer within the prostate."


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome." ScienceDaily. ScienceDaily, 9 November 2006. <www.sciencedaily.com/releases/2006/11/061108154701.htm>.
Fox Chase Cancer Center. (2006, November 9). Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2006/11/061108154701.htm
Fox Chase Cancer Center. "Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome." ScienceDaily. www.sciencedaily.com/releases/2006/11/061108154701.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins