Featured Research

from universities, journals, and other organizations

Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome

Date:
November 9, 2006
Source:
Fox Chase Cancer Center
Summary:
Researchers say an over-expression of COX-2 in men with prostate cancer is associated with an increase in PSA after radiation treatment and the spread of the cancer outside of the prostate. That is the result of the first study linking COX-2 with prostate cancer radiation treatment outcomes.

Researchers say an over-expression of COX-2 in men with prostate cancer is associated with an increase in PSA after radiation treatment and the spread of the cancer outside of the prostate. That is the result of the first study linking COX-2 (cyclooxygenase-2) with prostate cancer radiation treatment outcomes. The study, sponsored by the Radiation Therapy Oncology Group (RTOG 92-02), was presented today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia by Li-Yan Khor, M.D., a fellow in the Radiation Oncology Department at Fox Chase Cancer Center in Philadelphia.

"We found that an increased level of COX-2 prior to treatment was linked with biochemical failure and distant metastasis but was not predictive of overall survival," explained Khor.

For the study, Khor and colleagues analyzed 586 cases from RTOG 92-02 which had available tissue and suitable staining by immunohistochemistry. Median follow-up was 106.9 months. The intensity of COX-2 staining was quantified by automated image analysis provided by a commercial company.

The 5 year distant metastasis rate was 10.6 percent for a COX-2 intensity score less than 134, versus 14.1 percent for an intensity score greater than 134. A high intensity of COX-2 also predicted biochemical failure, the immediate PSA rise after treatment.

Khor added that data from animals have shown that inhibition of COX-2 suppresses angiogenesis (development of blood vessels) and the growth of prostate cancer, and is believed to make the cancer cells more sensitive to radiation therapy.

"This research suggest the need to know more about the levels of COX-2 in our patients," says Khor. "If men show increased levels of COX-2 perhaps radiation treatment will follow an attempt to inhibit COX-2 expression thereby making their cancer more responsive to radiation therapy."

Khor adds "Future studies in this area should include additional biopsy information to determine if COX-2 over-expression is associated with the inability to completely eliminate the cancer within the prostate."


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome." ScienceDaily. ScienceDaily, 9 November 2006. <www.sciencedaily.com/releases/2006/11/061108154701.htm>.
Fox Chase Cancer Center. (2006, November 9). Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2006/11/061108154701.htm
Fox Chase Cancer Center. "Over-expression Of Cox-2 Can Predict Prostate Cancer Outcome." ScienceDaily. www.sciencedaily.com/releases/2006/11/061108154701.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins