Featured Research

from universities, journals, and other organizations

Cognitive Disorders May Be Treatable With New Class Of Compounds

Date:
May 2, 2007
Source:
University of California - Irvine
Summary:
Researchers have identified a new class of compounds that could be used for drugs to treat cognitive disorders that accompany schizophrenia, Alzheimer's disease and ADHD. The compounds target receptors in the brain that are activated by nicotine, according to the article.

UC Irvine researchers have identified a new class of compounds that could be used for drugs to treat cognitive disorders that accompany schizophrenia, Alzheimer’s disease and ADHD, according to an article published in the online version of the Proceedings of the National Academy of Sciences.

The compounds target receptors in the brain that are activated by nicotine. They impart the beneficial effects of nicotine – specifically enhanced cognition – without the numerous health threats associated with smoking.

“We’d like to see this lead to a drug that would address specifically the cognitive deficits found in schizophrenia,” said Kelvin W. Gee, professor in the Department of Pharmacology, School of Medicine at UC Irvine. Some examples of such deficits include difficulty concentrating and adapting to change and poor memory, which makes it more difficult for them to remember to take their antipsychotic medication.

“We could probably treat more schizophrenics on an outpatient basis and allow them to re-enter mainstream society if we could address cognition,” Gee said.

Anecdotally, the effect of nicotine in the brains of schizophrenics has been noted for years, Gee said. Many people with the mental illness use tobacco as a sort of self-medication to help them think more clearly.

The three-year study conducted with rodents supported the anecdotal evidence, showing that activating a certain nicotinic receptor in the brain improved working memory and made it easier to filter sensory input. Additional animal work is needed to confirm findings and make sure the compound is safe before testing can be done with human subjects.

Gee was joined in the research by Herman Ng, Edward Whittemore, Minhtam Tran, Derk Hogenkamp, Ron Broide and Timothy Johnstone, all of UCI; and by Lijun Zhang and Karen Stevens, collaborators at the Department of Psychiatry, University of Colorado Health Sciences Center. Funding for the study came from a UC Discovery Grant and Xytis Pharmaceuticals.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "Cognitive Disorders May Be Treatable With New Class Of Compounds." ScienceDaily. ScienceDaily, 2 May 2007. <www.sciencedaily.com/releases/2007/05/070501172318.htm>.
University of California - Irvine. (2007, May 2). Cognitive Disorders May Be Treatable With New Class Of Compounds. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2007/05/070501172318.htm
University of California - Irvine. "Cognitive Disorders May Be Treatable With New Class Of Compounds." ScienceDaily. www.sciencedaily.com/releases/2007/05/070501172318.htm (accessed August 30, 2014).

Share This




More Mind & Brain News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com
Electrical Stimulation Boosts Brain Function, Study Says

Electrical Stimulation Boosts Brain Function, Study Says

Newsy (Aug. 29, 2014) Researchers found an improvement in memory and learning function in subjects who received electric pulses to their brains. Video provided by Newsy
Powered by NewsLook.com
Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins