Featured Research

from universities, journals, and other organizations

'Nondanger' Signal Lowers Immune Reactions

Date:
May 16, 2007
Source:
Children's Hospital of Philadelphia
Summary:
Rheumatology researchers have discovered that a well-known cell receptor sends a signal to dampen the immune system. While not having an immediate application to treating disease, the finding raises the possibility that by targeting that receptor, physicians could stimulate a "nondanger" signal to rein in overzealous human immune responses. Controlling those responses could potentially protect transplant patients from rejection episodes or could relieve symptoms of autoimmune diseases such as rheumatoid arthritis and lupus.

Rheumatology researchers have discovered that a well-known cell receptor sends a signal to dampen the immune system.

While not having an immediate application to treating disease, the finding raises the possibility that by targeting that receptor, physicians could stimulate a "nondanger" signal to rein in overzealous human immune responses. Controlling those responses could potentially protect transplant patients from rejection episodes or could relieve symptoms of autoimmune diseases such as rheumatoid arthritis and lupus.

Researchers from The Children's Hospital of Philadelphia and The University of Pennsylvania reported that complement receptor 3 (CR3), a protein found on cell surfaces, inhibits dendritic cells, the sentinels of the immune system, from setting off an alarm signal that brings on a full immune response.

"Normally, dendritic cells patrol different tissues and organs and look for danger signals sent by tissues undergoing stress or responding to invading microorganisms," said Stefania Gallucci, M.D., leader of the study team at The Children's Hospital of Philadelphia. "We found that when we stimulate CR3 on dendritic cells, CR3 sends a 'nondanger' signal that suppresses the ability of dendritic cells to set off an immune response," added Dr. Gallucci, who is also an assistant professor at the University of Pennsylvania.

In their study, the researchers used a monoclonal antibody, engineered to bind to CR3, to trigger a cascade of responses that had a net result of decreasing the activation of T cells that would normally be produced. T cells are immune cells that fight infection while contributing to the inflammation seen in an immune response.

"What is exciting about our research is that we have a new agent for modifying dendritic cell function," said pediatric rheumatologist Edward M. Behrens, M.D., the first author of the study. "The monoclonal antibody we used is already in a form that can be used for further studies. It has anti-inflammatory effects, so it may be a potential weapon against inflammatory diseases."

One such disease is lupus erythematosus, an autoimmune disease in children and adults that may damage many organs. A next step, said Dr. Gallucci, is to test the antibody in mice that have a disease similar to lupus in humans. The study team also expects to test the antibody in animal models of rheumatoid arthritis. In addition, the researchers may investigate a possible role for the antibody as an immunosuppressant, in preventing a patient's immune system from rejecting cell and organ transplants.

The study, which was performed in mice, appeared in the May 15 issue of the Journal of Immunology.

The National Institutes of Health, the Lupus Foundation Southeastern Pennsylvania Chapter and the Arthritis Foundation supported the study. Co-authors with Drs. Gallucci and Behrens, all from Children's Hospital and the University of Pennsylvania School of Medicine, were Terri H. Finkel, M.D., Ph.D.; Uma Sriram, Ph.D.; Debra K. Shivers; and Zhengyu Ma, Ph.D. Marcello Gallucci, Ph.D., of the University of Milano-Bicocca in Italy also was a co-author.


Story Source:

The above story is based on materials provided by Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital of Philadelphia. "'Nondanger' Signal Lowers Immune Reactions." ScienceDaily. ScienceDaily, 16 May 2007. <www.sciencedaily.com/releases/2007/05/070515153452.htm>.
Children's Hospital of Philadelphia. (2007, May 16). 'Nondanger' Signal Lowers Immune Reactions. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2007/05/070515153452.htm
Children's Hospital of Philadelphia. "'Nondanger' Signal Lowers Immune Reactions." ScienceDaily. www.sciencedaily.com/releases/2007/05/070515153452.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins