Featured Research

from universities, journals, and other organizations

Statin Use Linked With Decreased Prostate Cancer Mortality Rates; Lower PSA Levels

Date:
May 21, 2007
Source:
American Urological Association
Summary:
In recent years, research has indicated a possible link between dietary fat intake and prostate cancer. New research explores the effect statin medications (which work to reduce low-density lipoprotein, or LDL, levels) may have on prostate-specific antigen, the incidence of prostate cancer, and mortality due to prostate cancer.

Urologists and researchers have postulated in recent years that statin medications could have an impact on the growth and progression of prostate cancer. Cholesterol is a primary building block for testosterone, which has in turn been linked with prostate tumor growth (less testosterone results in slower-growing tumors). In recent years, research has indicated a possible link between dietary fat intake and prostate cancer.

Related Articles


Research presented at the 102nd Annual Scientific Meeting of the American Urological Association explores the effect statin medications (which work to reduce low-density lipoprotein, or LDL, levels) may have on prostate-specific antigen, the incidence of prostate cancer, and mortality due to prostate cancer.

Exploring Causes For Declining Prostate Cancer Mortality Rates In The United States Between 1993 And 2003

Researchers from the University of Alabama, Birmingham, sought to compare declining prostate cancer mortality rates with the independent epidemiological variables including prostate-specific antigen (PSA) screening, insurance coverage, obesity, diabetes and hyperlipidemia (high cholesterol levels). Results of the study showed a direct correlation between prostate-cancer mortality rates with hyperlipidemia and PSA screening in white men, and health insurance coverage in black men. The link between high cholesterol and declining mortality was unexpected, and researchers attribute this relationship to the increased use of statin medications to treat high cholesterol.

The Influence Of Statin Medications On Prostate-specific Antigen Levels In Healthy Men

High levels of LDL cholesterol have been associated with a variety of health concerns, including heart disease and, most recently, prostate cancer. As more men are prescribed statin medications to lower levels of "bad" cholesterol, prostate cancer growth has been shown to slow due to decreased levels of testosterone. Researchers from Duke University and Johns Hopkins University have explored whether statin medications affect not only prostate cancer growth, but also prostate-specific antigen levels in healthy men thereby posing a risk of not detecting the disease early.

The team examined 1,545 men who had been prescribed a statin between 1990 and 2006 at the Durham VA Medical Center. The men had a mean age of 60.1, median PSA of 0.92 ng/ml and mean pre-statin LDL level of 152 mg/dl. PSA changes were strongly linked with LDL changes; PSA levels declined by 1.1 percent for every 10 mg/dl decrease in LDL. Results suggest that statins influence prostate biology -- a factor that should be explored further to examine the significance that statin medications may have on prostate cancer detection.

Statins And Prostate Cancer Among Men Participating In The Finnish Prostate Cancer Screening Trial

Reviewing PSA levels among statin users screened in the Finnish Prostate Cancer Screening Trial, researchers from Helsinki found a decrease in prostate cancer incidence in this group, compared to those who did not take the drugs. A significant decrease was found in the incidence of T3 cancers and thos with a Gleason score ranging 5-6. Researchers also found lower serum PSA levels and free/total PSA ratios in this population.

Non-statin, lipid-lowering drugs were not associated with incidence, stage or grade.


Story Source:

The above story is based on materials provided by American Urological Association. Note: Materials may be edited for content and length.


Cite This Page:

American Urological Association. "Statin Use Linked With Decreased Prostate Cancer Mortality Rates; Lower PSA Levels." ScienceDaily. ScienceDaily, 21 May 2007. <www.sciencedaily.com/releases/2007/05/070520140914.htm>.
American Urological Association. (2007, May 21). Statin Use Linked With Decreased Prostate Cancer Mortality Rates; Lower PSA Levels. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2007/05/070520140914.htm
American Urological Association. "Statin Use Linked With Decreased Prostate Cancer Mortality Rates; Lower PSA Levels." ScienceDaily. www.sciencedaily.com/releases/2007/05/070520140914.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins