Featured Research

from universities, journals, and other organizations

Proteins' Role In Coronary Heart Disease

Date:
June 28, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Scientists provided the first large-scale identification of the proteins involved in coronary heart disease. The information will help to better understand the progression of the disease, improve diagnosis, and detect early pathological signs more efficiently. Coronary heart disease, which is characterized by abnormal thickening and narrowing of the blood vessels, is the first leading cause of death in the United States. But what happens inside the cells of these blood vessels is not completely understood.

Scientists provided the first large-scale identification of the proteins involved in coronary heart disease. The information will help to better understand the progression of the disease, improve diagnosis, and detect early pathological signs more efficiently.

Related Articles


Coronary heart disease, which is characterized by abnormal thickening and narrowing of the blood vessels, is the first leading cause of death in the United States. But what happens inside the cells of these blood vessels is not completely understood. One way to figure it out is by identifying the proteins present in blood vessels of heart disease patients, and then comparing them with those present in healthy blood vessels.

David K. Han and colleagues developed a technique called direct tissue proteomics that identified all the proteins expressed in the coronary arteries of heart disease patients. They found about 800 proteins, some of them not previously known to be involved in heart disease. The list of proteins, which is freely available to the scientific community, could help develop more effective therapies against coronary heart disease. The investigators also used another highly sensitive proteomics method to detect important cytokines directly from diseased coronary arteries, an approach that could uncover important biomarkers relevant to other diseases.

Article: "Proteomics Analysis of Human Coronary Atherosclerotic Plaque," by Carolina Bagnato, Jaykumar Thumar, Viveka Mayya, Sun-Il Hwang, Henry Zebroski, Kevin P. Claffey, Christian Haudenschild, Jimmy K. Eng, Deborah H. Lundgren and David K. Han


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Proteins' Role In Coronary Heart Disease." ScienceDaily. ScienceDaily, 28 June 2007. <www.sciencedaily.com/releases/2007/06/070626184147.htm>.
American Society for Biochemistry and Molecular Biology. (2007, June 28). Proteins' Role In Coronary Heart Disease. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2007/06/070626184147.htm
American Society for Biochemistry and Molecular Biology. "Proteins' Role In Coronary Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2007/06/070626184147.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins