Featured Research

from universities, journals, and other organizations

Proteins' Role In Coronary Heart Disease

Date:
June 28, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Scientists provided the first large-scale identification of the proteins involved in coronary heart disease. The information will help to better understand the progression of the disease, improve diagnosis, and detect early pathological signs more efficiently. Coronary heart disease, which is characterized by abnormal thickening and narrowing of the blood vessels, is the first leading cause of death in the United States. But what happens inside the cells of these blood vessels is not completely understood.

Scientists provided the first large-scale identification of the proteins involved in coronary heart disease. The information will help to better understand the progression of the disease, improve diagnosis, and detect early pathological signs more efficiently.

Related Articles


Coronary heart disease, which is characterized by abnormal thickening and narrowing of the blood vessels, is the first leading cause of death in the United States. But what happens inside the cells of these blood vessels is not completely understood. One way to figure it out is by identifying the proteins present in blood vessels of heart disease patients, and then comparing them with those present in healthy blood vessels.

David K. Han and colleagues developed a technique called direct tissue proteomics that identified all the proteins expressed in the coronary arteries of heart disease patients. They found about 800 proteins, some of them not previously known to be involved in heart disease. The list of proteins, which is freely available to the scientific community, could help develop more effective therapies against coronary heart disease. The investigators also used another highly sensitive proteomics method to detect important cytokines directly from diseased coronary arteries, an approach that could uncover important biomarkers relevant to other diseases.

Article: "Proteomics Analysis of Human Coronary Atherosclerotic Plaque," by Carolina Bagnato, Jaykumar Thumar, Viveka Mayya, Sun-Il Hwang, Henry Zebroski, Kevin P. Claffey, Christian Haudenschild, Jimmy K. Eng, Deborah H. Lundgren and David K. Han


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Proteins' Role In Coronary Heart Disease." ScienceDaily. ScienceDaily, 28 June 2007. <www.sciencedaily.com/releases/2007/06/070626184147.htm>.
American Society for Biochemistry and Molecular Biology. (2007, June 28). Proteins' Role In Coronary Heart Disease. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2007/06/070626184147.htm
American Society for Biochemistry and Molecular Biology. "Proteins' Role In Coronary Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2007/06/070626184147.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins