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Spot On Treatment For Acne

Date:
August 15, 2007
Source:
Society of Chemical Industry
Summary:
A previously unknown side effect of an unnamed drug currently on the marketplace could be useful for treating acne. A UK company is about to start a Phase 1 trial with the drug. In an earlier phase 1 study in nine healthy human volunteers, the treatment was seen to reduce the excretion of sebum by the skin, which is associated with acne development, by up to 70 percent.
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A previously unknown side effect of an unnamed drug currently on the marketplace could be useful for treating acne, reports Chemistry & Industry, the magazine of the SCI. A UK company is about to start a Phase 1 trial with the drug involving 18 healthy human volunteers and the results are expected to be announced later this year. In an earlier Phase 1 study in nine healthy human volunteers, the treatment was seen to reduce the excretion of sebum by the skin, which is associated with acne development, by up to 70%.

'The Phase I results are startlingly good,' said Nigel Blackburn, director of clinical development at the company, Summit, which is organising the trial. 'Reducing sebum production has been the "holy grail" of acne treatment for 30 years, and there has been little success aside from Roaccutane which has significant side effects.'

The current 'gold standard' for acne treatment, Roaccutane can cause a wide range of side effects, including teratogenicity -- which leads to abonormalities in the unborn foetus of pregnant women, and has also recently been linked to depression and (inconclusively) to teenage suicides. The market for acne treatments is worth several billion dollars, and any new treatment developed without side effects could potentially reap blockbuster sales.

Although Summit has not disclosed the name of the drug now under evaluation, the company says it represents an entirely new class of compounds for treating acne. 'At the doses we are looking at any side effects should be mild compared with those resulting from Roaccutane treatment,' Blackburn commented.

The company hopes to begin critical Phase 2 trials to assess the efficacy of the drug in acne sufferers next year. Depending on the results, the drug could either be formulated as a stand-alone topical treatment or more likely in combination with other existing treatments. The company has already been in talks with several interested companies, who are waiting to see whether the initial results can be repeated in a larger study group.

About acne

Acne develops when too much sebum is produced in the skin and the sebaceous glands are infected by the bacterium Propionibacterium acnes. The condition affects up to 80-90% of adolescents, and approximately 30% of people continue with their acne into adult life, according to the UK Primary Care Dermatology Society. The incidence of acne at age 40 is reported to be 1% in men and 5% in women.


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The above post is reprinted from materials provided by Society of Chemical Industry. Note: Materials may be edited for content and length.


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Society of Chemical Industry. "Spot On Treatment For Acne." ScienceDaily. ScienceDaily, 15 August 2007. <www.sciencedaily.com/releases/2007/08/070813083053.htm>.
Society of Chemical Industry. (2007, August 15). Spot On Treatment For Acne. ScienceDaily. Retrieved September 2, 2015 from www.sciencedaily.com/releases/2007/08/070813083053.htm
Society of Chemical Industry. "Spot On Treatment For Acne." ScienceDaily. www.sciencedaily.com/releases/2007/08/070813083053.htm (accessed September 2, 2015).

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