Featured Research

from universities, journals, and other organizations

How Tumors Prevent Immune Cell Entry

Date:
August 22, 2007
Source:
Journal of Clinical Investigation
Summary:
For a number of cancers the presence of immune cells known as an NKT cells in the tumor is associated with a better prognosis. It has therefore been suggested that more aggressive tumors have developed strategies to prevent them from being infiltrated by NKT cells. A new study shows that this is the case. The pathway used by tumors to prevent NKT cell infiltration might provide researchers with new targets for the development of new treatments for cancer.

For a number of cancers the presence of immune cells known as an NKT cells in the tumor is associated with a better prognosis. It has therefore been suggested that more aggressive tumors have developed strategies to prevent them from being infiltrated by NKT cells.

A new study, published online on August 16 in advance of publication in the September print issue of the Journal of Clinical Investigation, shows that this is the case. The pathway used by tumors to prevent NKT cell infiltration might provide researchers with new targets for the development of new treatments for cancer.

In the study, Leonid Metelitsa and colleague from Childrens Hospital Los Angeles show in vitro that expression of a protein known as MYCN, which has been associated with many different types of cancer, by neuroblastoma cells decreases their secretion of a soluble factor (CCL2) that attracts NKT cells.

Similarly, in mice, NKT cells were largely inhibited from invading neuroblastomas overexpressing MYCN. Furthermore, individuals with neuroblastomas that expressed high levels of MYCN and whose cancer had spread to the bone marrow had substantially fewer NTK cells in their bone marrow than individuals with neuroblastomas that expressed low levels of MYCN and whose cancer had spread to the bone marrow.

The authors therefore suggest that enhancing NKT cell localization to the tumor should be considered when designing new cancer therapeutics.

Article: Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "How Tumors Prevent Immune Cell Entry." ScienceDaily. ScienceDaily, 22 August 2007. <www.sciencedaily.com/releases/2007/08/070818085336.htm>.
Journal of Clinical Investigation. (2007, August 22). How Tumors Prevent Immune Cell Entry. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2007/08/070818085336.htm
Journal of Clinical Investigation. "How Tumors Prevent Immune Cell Entry." ScienceDaily. www.sciencedaily.com/releases/2007/08/070818085336.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins