Featured Research

from universities, journals, and other organizations

Natural Protection Provides Possible New Treatments For Stroke

Date:
August 27, 2007
Source:
Goteborg University
Summary:
Two substances that occur naturally in the brain act to protect the brain during a stroke. This is the conclusion of a dissertation published at the Sahlgrenska Academy, and the discovery may lead to new treatments for stroke patients. Stroke is the result of an infarction, or bleeding, within the brain, and it may lead to impaired movement, impaired sensation, and difficulties in cognitive function and speech. Approximately 30,000 people are affected by stroke each year in Sweden, and it is the most common cause of long-term dependence on care.

Two substances that occur naturally in the brain act to protect the brain during a stroke. This is the conclusion of a dissertation published at the Sahlgrenska Academy, and the discovery may lead to new treatments for stroke patients.

Stroke is the result of an infarction, or bleeding, within the brain, and it may lead to impaired movement, impaired sensation, and difficulties in cognitive function and speech. Approximately 30,000 people are affected by stroke each year in Sweden, and it is the most common cause of long-term dependence on care.

"Researchers all over the world are intensively searching for new treatments. One interesting possibility is that of activating stem cells in the damaged brain such that the brain can be repaired and regain its function", says stem cell researcher Jonas Faijerson.

Stem cells are immature cells that reside in selected regions of the adult brain. These cells can develop either into nerve cells or into other cells that are important in the brain, such as astrocytes. Astrocytes are the most abundant cell type in the brain, and they play an important role when the brain is damaged.

The dissertation shows that activated astrocytes release substances that activate stem cells within the brain.

"We have shown that a very interesting hormone known as 'TRH' is released in large amounts after a stroke, and that this hormone can not only protect from damage but also lead to the activation of stem cells", says Jonas Faijerson.

The stem cells also release survival factors to the surrounding brain tissue when the brain is injured or diseased. The dissertation describes the identification of a completely unknown survival factor, which the researchers have named "pentinin". "Pentinin protects brain cells from several of the effects that a stroke causes. Both TRH and pentinin are interesting candidates for the development of new treatment strategies for patients with stroke. It is possible that these substances could be given in tablet form, as a drop, or as a nasal spray, when a stroke is suspected", says Jonas Faijerson.

The research has been carried out at the Centre for Brain Repair and Rehabilitation at the Sahlgrenska Academy.

Dissertation submitted for the degree of Ph. D. in Medicine at the Sahlgrenska Academy, Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and Rehabilitation

Title of the dissertation: Neural Stem/Progenitor cells in the Post-ischemic Environment: Proliferation, Differentiation and Neuroprotection The dissertation has been successfully defended.


Story Source:

The above story is based on materials provided by Goteborg University. Note: Materials may be edited for content and length.


Cite This Page:

Goteborg University. "Natural Protection Provides Possible New Treatments For Stroke." ScienceDaily. ScienceDaily, 27 August 2007. <www.sciencedaily.com/releases/2007/08/070824214944.htm>.
Goteborg University. (2007, August 27). Natural Protection Provides Possible New Treatments For Stroke. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2007/08/070824214944.htm
Goteborg University. "Natural Protection Provides Possible New Treatments For Stroke." ScienceDaily. www.sciencedaily.com/releases/2007/08/070824214944.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins