Featured Research

from universities, journals, and other organizations

Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis

Date:
October 17, 2007
Source:
World Journal of Gastroenterology
Summary:
Severe acute pancreatitis is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 percent-30 percent of mortality mainly due to multiple organ failure at its early stage. A research group in Hangzhou, China found that the Baicalin, main effective ingredient of Baical skullcap root, has played a protective role on renal injury of rats with SAP.

Severe acute pancreatitis is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 percent-30 percent of mortality mainly due to multiple organ failure at its early stage. A research group in Hangzhou, China found that the Baicalin, main effective ingredient of Baical skullcap root, has played a protective role on renal injury of rats with SAP.

'Qingyitang' a representative prescription of Traditional Chinese Medicine for severe acute pancreatitis (SAP) was widely used in the orients countries. But its real pharmacological mechanisms of protective effects on SAP have not been investigated still now.

Baicalin, the most effective monomer of Baical skullcap root (an essential Traditional Chinese Medicine of 'Qingyitang'), which have been proved a protective effects on renal injury of rats with SAP.

It has been confirmed that Baicalin has anti-bacterial, antiviral and anti-inflammatory activities in vitro. It also can inhibit platelet aggregation and eliminate oxygen-free radicals. Animal experiments show that Baicalin could reduce the generation of endotoxin. In addition, Baicalin has potent effect in inhibiting pancreatin which is the initial metabolite of Baicalin. All these pharmacologic actions can inhibit SAP during its multiple stages.

The research team led by Dr. Zhang Xiping from the first people's hospital of Hangzhou and second affiliated hospital of Zhejiang university spent more than five years working with experimental SAP of rats by the intravenous injection of Baicalin treatment. With the large dosage of baicalin treatment, the rats' survival rate, renal function indexes, renal gross changes and lightmicroscopic changes and its severity scores was greatly improved in end. The article clarified that the therapeutic mechanisms might be related to the inhibition of inflammatory mediators and induction of renal cells apoptosis by the application of tissue microarray technique.

Compared with the Octreotide, the most effective drug in the treatment of SAP, the large dosage Baicalin has equally effective as octreotide in terms of reduction of renal pathological alterations of rats with SAP. But for Octreotide, It is difficult to popularize especially in remote areas with poor economy since it features high price, short half-life and inconvenient administration, while Baicalin features low price, extensive routes of administration and preparation, multiple pharmacologic actions and precise therapeutic effects.

So the Baicalin might be a promising therapeutic medicines in the treatment of SAP despite there are still many works to be done future.

The research was recently published on October 14 issue of the World Journal of Gastroenterology .

Reference: Zhang XP, Tian H, Lai YH, Chen L, Zhang L, Cheng QH, Yan W, Li Y, Li QY, He Q, Wang F. Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(38): 5079-5089


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

World Journal of Gastroenterology. "Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis." ScienceDaily. ScienceDaily, 17 October 2007. <www.sciencedaily.com/releases/2007/10/071017102042.htm>.
World Journal of Gastroenterology. (2007, October 17). Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2007/10/071017102042.htm
World Journal of Gastroenterology. "Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis." ScienceDaily. www.sciencedaily.com/releases/2007/10/071017102042.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins