Featured Research

from universities, journals, and other organizations

Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis

Date:
October 17, 2007
Source:
World Journal of Gastroenterology
Summary:
Severe acute pancreatitis is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 percent-30 percent of mortality mainly due to multiple organ failure at its early stage. A research group in Hangzhou, China found that the Baicalin, main effective ingredient of Baical skullcap root, has played a protective role on renal injury of rats with SAP.

Severe acute pancreatitis is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 percent-30 percent of mortality mainly due to multiple organ failure at its early stage. A research group in Hangzhou, China found that the Baicalin, main effective ingredient of Baical skullcap root, has played a protective role on renal injury of rats with SAP.

Related Articles


'Qingyitang' a representative prescription of Traditional Chinese Medicine for severe acute pancreatitis (SAP) was widely used in the orients countries. But its real pharmacological mechanisms of protective effects on SAP have not been investigated still now.

Baicalin, the most effective monomer of Baical skullcap root (an essential Traditional Chinese Medicine of 'Qingyitang'), which have been proved a protective effects on renal injury of rats with SAP.

It has been confirmed that Baicalin has anti-bacterial, antiviral and anti-inflammatory activities in vitro. It also can inhibit platelet aggregation and eliminate oxygen-free radicals. Animal experiments show that Baicalin could reduce the generation of endotoxin. In addition, Baicalin has potent effect in inhibiting pancreatin which is the initial metabolite of Baicalin. All these pharmacologic actions can inhibit SAP during its multiple stages.

The research team led by Dr. Zhang Xiping from the first people's hospital of Hangzhou and second affiliated hospital of Zhejiang university spent more than five years working with experimental SAP of rats by the intravenous injection of Baicalin treatment. With the large dosage of baicalin treatment, the rats' survival rate, renal function indexes, renal gross changes and lightmicroscopic changes and its severity scores was greatly improved in end. The article clarified that the therapeutic mechanisms might be related to the inhibition of inflammatory mediators and induction of renal cells apoptosis by the application of tissue microarray technique.

Compared with the Octreotide, the most effective drug in the treatment of SAP, the large dosage Baicalin has equally effective as octreotide in terms of reduction of renal pathological alterations of rats with SAP. But for Octreotide, It is difficult to popularize especially in remote areas with poor economy since it features high price, short half-life and inconvenient administration, while Baicalin features low price, extensive routes of administration and preparation, multiple pharmacologic actions and precise therapeutic effects.

So the Baicalin might be a promising therapeutic medicines in the treatment of SAP despite there are still many works to be done future.

The research was recently published on October 14 issue of the World Journal of Gastroenterology .

Reference: Zhang XP, Tian H, Lai YH, Chen L, Zhang L, Cheng QH, Yan W, Li Y, Li QY, He Q, Wang F. Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol 2007; 13(38): 5079-5089


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

World Journal of Gastroenterology. "Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis." ScienceDaily. ScienceDaily, 17 October 2007. <www.sciencedaily.com/releases/2007/10/071017102042.htm>.
World Journal of Gastroenterology. (2007, October 17). Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2007/10/071017102042.htm
World Journal of Gastroenterology. "Baicalin Might Be A Promising Therapeutic Tool For Severe Acute Pancreatitis." ScienceDaily. www.sciencedaily.com/releases/2007/10/071017102042.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins