Featured Research

from universities, journals, and other organizations

Extra Radiation Dose Prevents Breast Cancer Return In Young Women, Study Suggests

Date:
October 30, 2007
Source:
American Society for Therapeutic Radiology and Oncology
Summary:
Women 40 years and younger with early-stage breast cancer who receive an additional high dose of radiation after undergoing breast-conserving surgery and standard radiation treatment are almost twice as likely to be free of cancer 10 years after treatment compared to those who don't receive the boost dose.

Women 40 years and younger with early-stage breast cancer who receive an additional high dose of radiation (boost dose) after undergoing breast-conserving surgery (lumpectomy) and standard radiation treatment are almost twice as likely to be free of cancer 10 years after treatment compared to those who don't receive the boost dose, according to a large European study.

Related Articles


Although younger women benefitted most from an extra dose of radiation, the findings show that women of all ages who had a boost dose of radiation after standard treatment were more likely to be cancer-free over a 10-year period.

The study involved 5,318 women who underwent lumpectomies and whole breast radiation treatment as part of their breast conserving therapy for Stage I and Stage II breast cancer and were evaluated 10 years later. Researchers wanted to determine if a boost dose of radiation following this treatment would decrease the risk of breast cancer recurrence. In addition to this, a sub-group of 1,725 patients were evaluated to find out the highest risk factors for localized breast cancer recurrence.

"The study found that the largest benefits of the boost dose of radiation after standard breast conserving treatment is seen in young women, who have a higher risk to breast cancer recurrence to begin with," said Harry Bartelink, M.D., Ph.D., the senior author of the study and professor and radiation oncologist at The Netherlands Cancer Institute at Antoni van Leeuwenhoek Hospital in The Netherlands.

For patients with early stage breast cancer, the current standard treatment involves breast conserving surgery (lumpectomy), followed by radiation therapy to the breast over a six to eight week period to kill any remaining cancer cells. In this study, an additional boost of high-dose radiation was given after conventional radiation therapy to the lumpectomy site where the tumor was removed to potentially increase the chances of a cure.

With a lumpectomy, the surgeon removes the tumor, along with nearby healthy tissue. If the outside of the tumor, or margin, has cancer cells present, then it's considered a positive margin. If it's unclear, or a very small distance, then doctors call it a close margin. Women who have positive and close surgical margins are at a higher risk of breast cancer returning, compared to those who have negative margins that are free of cancer.

The study also found that early-stage breast cancer patients who were at a younger age are most likely to have their cancer come back (recurrence), particularly those who have positive surgical margins. This study and previous ones have shown that young patients with early-stage breast cancer have a higher risk of breast recurrence, compared to older patients because their cancer tends to be more aggressive.

The abstract "The Impact Of Boost Dose And Margins On The Local Recurrence Rate In Breast Conserving Therapy: Results From The Eortc Boost- No Boost Trial," was presented at the Plenary I session on October 29, 2007, at the American Society for Therapeutic Radiology and Oncology's 49th Annual Meeting in Los Angeles.

.


Story Source:

The above story is based on materials provided by American Society for Therapeutic Radiology and Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Therapeutic Radiology and Oncology. "Extra Radiation Dose Prevents Breast Cancer Return In Young Women, Study Suggests." ScienceDaily. ScienceDaily, 30 October 2007. <www.sciencedaily.com/releases/2007/10/071029172926.htm>.
American Society for Therapeutic Radiology and Oncology. (2007, October 30). Extra Radiation Dose Prevents Breast Cancer Return In Young Women, Study Suggests. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2007/10/071029172926.htm
American Society for Therapeutic Radiology and Oncology. "Extra Radiation Dose Prevents Breast Cancer Return In Young Women, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2007/10/071029172926.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins